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Lecture 8

PSYC 3014 Lecture Notes - Lecture 8: Genetic Epidemiology, Human Genome Project, Blind Experiment


Department
Psychology
Course Code
PSYC 3014
Professor
R T Jones
Lecture
8

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Chapter 4 Day 2
THINGS DO NOT CHANGE UNTIL TREATMENT IS IMPLEMENTED
Repeated Measures Design
The same behavior over time
Group Designs
Comparative treatment designs
o Clinical trials CBT, PE, Drugs (SSRI's)
Compares different forms of treatment in similar persons -
o Treatment process (why it works)
Prolonged exposure
o Treatment outcomes (what are the results)
o Efficacy (fully controlled environment-lab) - very controlled environment, temp, day, time,
breakfast, EVERYTHING
o Effectiveness (real world, school, or home) - done in the real world, comparison, don't have
as much control over things.
Research by experiment
Control groups - you expect the experimental group will do better than the control
o Matched control groups
Age, gender, socioeconomic, etc.
o Placebo control groups (expectation or sugar pill) - drug studies
o Single blind control (participants) - don't tell them they're the control group
o Double blind control (therapist)
Genetics and Research Across Time
Strategies used in genetic research - depression, anxiety, schizophrenia, PTSD
o Basic genetic epidemiology - just looking at data, statistical analysis of family, twin, and
adoption studies
Is the disorder inherited and if so, how much of the disorder is attributable to genetics
o Advanced genetic epidemiology - statistical analysis of family, twin, and adoption studies
If the disorder is found to be inherited what are the factors that influence the disorder
o Gene finding - what's the gene or combo of genes, statistical analysis of specific families or
individuals (linkage and/or association studies)
Where is the gen (or genes) that influences the disorder?
USE THE PSYCHOPHYSIOLOGY
o Molecular genetics (biological analysis of individual DNA examples
What biological processes do the genes affect to produce the symptoms of the
disorder?
Behavioral genetics
o Interaction of genes, experience, and behavior
o Phenotype (what you look like)
o Genotype (unique genetic makeup)
o Human genome project (1990 study of all genes in an organism - 25,000 genes)
o Endophenotypes (genetic mech causing symptoms - genes or gene that cause memory
problems in schizo
o NOT THE SCHIZOPHRENIC GENE - seriously underfunded, didn't know a lot about it - much
more funded now because now we know about genes
Studying Behavior over time
Time based research strategies
o Cross-sectional designs
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