PSYC 3014 Lecture Notes - Lecture 16: Dopamine Antagonist, Basal Ganglia, Phencyclidine
Document Summary
Little impact on negative symptoms: antagonists don"t always work, olanzapine (weak dopamine antagonist) - doesn"t always do what we want, additional layer of complexity . (ooooh ominous, current theories suggest 3 specific neurochemical abnormalities that increase schizo symptoms. Large ventricles (lateral and 3rd ventricle: may not be size but adjacent parts of brain either not developed or atrophied, csf - bathes and cushions brain and spinal cord. In the dorsolateral prefrontal cortex there is too much activity (hyperfrontality: other subcortical circuits impacted: thalamus and striatum, prenatal and perinatal influences, viral infections. Influenza: delivery complications, asphyxia - difficulty breathing, chronic and early use of marijuana. Likely interaction with genetics and environment: psychological and social influences. Little benefit, more possible harm: 1930s to 1940s. Insulin coma therapy: psychosurgery - prefrontal lobotomies, electroconvulsive therapy, antipsychotic medications (neuroleptics - haldol and thorazine) First line of treatment: began in 1950s, decrease positive symptoms.
