BIO 422 Lecture Notes - Lecture 14: Metastasis, Blood Vessel, Angiogenesis
22 Aug 2019
School
Department
Course
Professor
Document Summary
Last time we finished up with angiogenesis: this was loosening up of extracellular matrix, there is also breakdown of collagen fibers, this all allows for the new blood vessels to form. If you have cells from a tumor trying to get free of the tumor and getting into the matric the extracellular matrix remodeling also plays a role: metastasis overview, you have the primary tumor. It will break through basement membrane: the cells will move through the basement membrane and invade the capillary. It will recruit a polycomb repressor complex: this is a silencing mechanism. Integrins are interacting with the collagen fibers: so, this stable structure has to be disrupted, so, if you don"t get rid of e-cadherin then you can"t have metastasis. In order to get movement of these cells though the basement membrane the cytoskeleton has to reorganize it self. It can"t just be a stable structure it will be able to form filipodia.
