BIO 230 Lecture Notes - Lecture 8: Chromatin, Nitrogenous Base, Ribozyme
10 Apr 2018
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Chapter 8 rna: transcription and processing11/1/2016 3:35:00 pm. Chemical components of nucleotide sugar, phosphate, nitrogen base. Dna with higher g content is more stable. Coding vs. noncoding strand: nontemplate strand = coding strand = 5" 3", template strand = noncoding strand = 3" 5". Transcription in eukaryotes: similar to transcription in prokaryotes but more complicated, 3 primary reasons for more complexity, larger eukaryotic genome (more genes, presence of the nucleus, genomic dna is organized into chromatin in eukaryotes. Nucleus in eukaryotes: rna processing, modify rna after it has been transcribed, must remove introns, put exons together, primary transcript (pre-mrna) differs from (processed transcript (mrna) Start site: only 1 or -1, not 0. Addition of a 3" poly a tail (polyadenylation: experiments have now shown that processing takes place cotranscriptionally, cotranscriptional processing. Rna splicing: the removal of introns, discovered in 1977, occurs in the mrnas, also something called alternative splicing. Spliceosome assembly and function: no u3 ^^^
