HLT 3400 Lecture 10: Exam 4 Pharm Study Guide
Document Summary
Erythocytic stage after incubation; merozoites enter rbcs and multiply. Rbcs rupture, releasing merozoites cold stage, hot stage, sweating stage. Primaquine prevents relapse, used to treat pcp in combo with clindamycin. Hydroxychloroquine prevention and treatment of malaria; retinal toxicity is a concern. For chloroquine: started 1-2 weeks prior to travel, taken weekly, taken for 4 weeks after travel also. Other drugs: taken 1-2 days prior to travel, taken daily, taken up to 7 days after trip; or weekly like chloroquine. Antihelmitics: when do we administer an antihelmitic, when the infestation is severe or if complications occur, resistance is not a clinical problem with antihelminthics. To taste: abdominal pain, distension, and diarrhea, serious adverse effects: seizures (rare), agranulocytosis, angioedema. Retroviruses -- hiv: acyclovir, treats hsv-1 and hsv-2 (most common drug for this), effective only at high doses for cmv and varicella zoster, 5-10 days of po, neonatal not associated with teratogenic effects.
