E62 BME 140 Lecture Notes - Lecture 13: Ideal Gas Law, Stress (Mechanics), Degenerative Disease
28 Dec 2015
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Document Summary
Discs in between each vertebrae in the spine. Lumbar degenerative disease disorder: damages discs and reduces its ability to dampen impact. Load support in the ivd: axial stresses due to weight-bearing. axial compressive stress. Protein core in the body is negatively charged due to sulfates being added to it. Attracts a large quantity of sodium ions and some calcium ions due to concentration of the two. Ideal gas law: pv = nrt or p = (n/v) rt. Osmotic pressure where is mobile ion concentration gradient due to negative charges in np. Loss of cells loss of water and proteoglycan. Loss of water and proteoglycan loss of nucleus pulposus pressurization (biochemical changes, endplate changes) nuclear or anular tears or clefts associated with altered strains. Altered disc geometry (eg loss of disc height, altered endplate curvature) Arthrodesis for stabilization of the unstable motion segment. Loss of motion (altered compression, osmotic or hydrostatic pressure, tension)
