E62 BME 140 Lecture Notes - Lecture 4: Biomaterial, Oct-4, Platelet-Derived Growth Factor
17 Sep 2015
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Document Summary
Mimicking the natural extracellular matrix with synthetic materials for regenerative medicine. Proteins adsorption on surfaces: almost regardless of surface chemistry, biomaterials are rapidly covered with a monolayer of adsorbed protein (about 200 ng/ c m2 a protein-containing solution. Resistance to nonspecific protein interactions is fundamental to achieving specific biological interactions. Proteins in plasma and cells tend to be negatively charged and decorated with polysaccharides. Non-specific interactions of ligands with cell surfaces are present but amounts are small compared to specific binding with receptors. One key aspect is that the systems are self-renewing - resistance to protein interaction only needs to be on the order of days to weeks. Proteins involved in wound healing adsorb on biomaterials, recruiting cells involved in wound healing and causing cells to adopt a wound healing phenotype. Process: 1) implantation -> 2) protein adsorption -> 3) immune response (complement or antibodies) neutrophils, monocytes/macrophage -> 4) pdgf, fgf, interleukins tgf , ,
