L07 Chem 481 Lecture 13: Lecture 13
5 Mar 2017
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If1 is regulated by ph (concentration of h+, so based on proton gradient for atp synthase) ph < 6. 5 -> if1 dimerizes -> inhibit complex v. Prevents (cid:533) subunit from undergoing conformational changes which stops the (cid:534) subunit from spinning thus shutting down complex v. If1 inhibits complex v when ph is low because that means the etc not working b/c protons not being pumped out. Prevents atp hydrolysis because proton gradient would be going the other direction causing complex v from spinning clockwise. Symporter (phosphate translocase): brings h2po4- (inorganic phosphate) and. H+ (4th proton involved in atp synthesis) into the matrix at the same time. If this doesn"t work, then matrix will run out of inorganic phosphates which will eventually cause no more atp synthesis. Complex v, phosphate translocase, and ant together are called the synthasome. Nadh + h+ -> nad+ (coupled with the reaction) Transfers a nh2 to oxaloacetate to make aspartate.
