Linoleic Acid (18:2)
1) Acetyl CoA Carboxylase
FAS1 (Fatty Acid Synthase 1):
Must be a homodimer to be fully activated. Fatty Acid Synthase 1 (FAS 1) 1) Addition of Acetyl group from Acetyl-CoA a) Acetyl group attached to an S attached to the KS
b) Malonyl group added from Malonyl-CoA.
c) Have a malonyl group attached to an S attached to ACP and Acetyl group to S to
2) Condensation (KS)
a) Malonyl group attacks Acetyl group and releases a CO2 from the carboxyl group
of the malonyl group.
b) S on KS is protonated now.
c) ACP attached to S-C=O-CH2=C=O-CH3 (4 carbon molecule with S)
3) Reduction of β-keto group (KR)
a) Converts an NADPH + H+ -> NADP+
4) Dehydration (DH)
5) Reduction of C=C (ER)