BIOL 155

Human Biology

University of British Columbia

An examination of the structure, function, and behavior of eukaryotic chromosomes. Cross-listed with BPSC 155.

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Robert Harris

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Biology
BIOL 155
Robert Harris

BIOL 155 Syllabus for Robert Harris — Fall 2018

1
Biology 153: Human Anatomy and Physiology
Biology 155: Human Physiology
Winter 2017/18
Course Descriptions
Biology 153 (7 credit) is designed for, but not restricted to students in Dental Hygiene,
Midwifery, Food & Nutrition Science, and applying for entry into the School of Nursing.
Prerequisites include Biology 11 or 12 plus Chemistry 11 and 12 (or equivalent). Biology 155 (6
credit) is the lecture portion of the biology 153 course and is open to the general student body. We
assume that students have some previous knowledge of biological principles and basic organic
chemistry.
Biology 153 has two components: lecture (2.8 hr/week) and laboratory (3 hr/week). Lectures
emphasize the understanding of basic concepts in biology, such as the function of enzymes or the
role of major cellular organelles, as well as the fundamental concepts in human physiology, such as
ionic mechanisms of generation of action potentials or kidney function. In addition, the importance
of interactions between organ systems to maintain homeostasis is stressed throughout the year.
Most laboratories emphasize the relationship between structure and function of the human body,
allowing students to relate the laboratory material to the physiological concepts studied in lectures.
In addition, the bulk of the instruction in Anatomy is accomplished in the laboratory sessions.
Finally, several laboratories involve hands-on experiments that investigate organ physiology or test
responses of the human organism to changes in the environmental conditions.
The thorough approach to study of the human anatomy and physiology offered in Biology 153 is
designed to equip students for successful completion of courses in the Nursing Program, as well as
Dental Hygiene and Midwifery, and, more importantly, for future practice in these professions.
Overall Course Objectives
By the end of this course students are expected to:
1.
Have developed thorough understanding of fundamental concepts in human physiology,
interactions between major physiological systems, and the effects of selected pathological
conditions on the function of these systems and their specific organs.
2.
Have developed solid knowledge of human anatomy including the understanding of the cause-
effect relationship between structure and function of tissues, organs, and systems.
3.
Be able to think critically about the importance and impact of physiology of the human body on
the nursing practice.
4.
Have demonstrated a high degree of maturity and professionalism expected of future health care
professionals.
Biology 155 is the lecture-only version of this program (2.8 hr/week). As such, it is primarily a
foundational course in human physiology, suitable for students in General Sciences, Biology, and as
a preparatory course for the Health Sciences, including Medicine and Dentistry (Biol 155 is not a
pre-requisite for these programs). The focus is to study human physiology and understand how
physiological changes enable the human body to adapt to varying environmental challenges. As
stated above for Biol 153, lectures emphasize the understanding of basic concepts in biology, such
as the function of enzymes or the role of major cellular organelles, as well as the fundamental
concepts in human physiology, such as ionic mechanisms of generation of action potentials or
kidney function. In addition, the importance of interactions between organ systems to maintain
homeostasis is stressed throughout the year.
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Lecturer/Lab Coordinator Dr. Robert A. Harris 604.822.5709 [email protected]ology.ubc.ca
Office #: Rm. 2116A, D.H. Copp Building
Office hours: M & Fri 10:00 - 12:30, or by appointment
Lectures: Sec. 001 T. Th. 3:30 - 5:00 PM
West Mall Swing Space room 222
Sec. 002 M,W,F 5:00 - 6:00 PM
Westbrook room 100
Labs: (153 only) L01 M. 13:00 - 16:00
L0-2 T. 9:00 - 12:00
Rm. 2116 L03 W. 9:00 - 12:00 L04 W. 13:00 - 16:00
D.H. Copp L05 Th. 9:00 - 12:00
Building L06 F. 9:00 - 12:00 L07 F. 13:00 - 16:00
Tutorial: T01 Th. 1:00 - 2:00 West Mall Swing Space room 221
T03 T 12:00 - 1:00 Neville Scarfe Building 210
Required Texts:
_ Martini, F. H. "Visual Anatomy & Physiology", 2nd Ed.
Required Equipment:
3-ring binders to file lecture notes, lab notes, and lab reports
USB drive or memory stick for saving lab data
Optional (but highly recommended) Texts:
Medical Dictionary
The Internet:
The following web site will have the lecture material posted in a downloadable format:
http://www.zoology.ubc.ca/~harris
Note: Although the internet has become a major source of scientific information you should
remember that, unlike scientific papers or textbooks, most web sites do not undergo the process of
peer review. Consequently, never assume that everything posted on the web is correct, and when
surfing the net choose web sites that belong to well-established institutions such as major colleges
and universities.
Evaluation
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The distribution of marks in Biology 153 is as follows:
Lecture: 60%
Lab: 40%
Course Total: 100%
The lecture mark is based on:
One mid-term exam in each term: 20% (Oct. and March.; 10% each)
Winter exam: 20%
Final exam: 20%
Total: 60%
Biology 155 marks will be based solely on the lecture exams, which will be weighted as follows:
One mid-term exam in each term: 30% (Oct. and Feb.; 15% each)
Winter exam: 35%
Final exam: 35%
Total: 100%
The lecture exams last either 80 minutes (midterms) or 2 hours (winter and final exams) and consist
of several questions requiring short to medium length essay style answers and designed to test the
overall comprehension and ability to integrate larger volumes of material.
Lecture Grading Criteria (General Guidelines)
A level (80-100%) - Work of Outstanding Quality
Suggests that there is very high quality throughout every aspect of your work including outstanding
to very good comprehension of the lecture material, ability to integrate information in a clear and
logical manner, and a very high degree of engagement with and interest in the subject.
B level (68-79%) - Work of Good Quality with no Major Weaknesses
Suggests that there is generally a good quality throughout your work, with a few to several problems
of minor significance. Good comprehension of lecture material with several to a few examples
showing the ability to integrate information in a clear and logical manner. Relatively high to fair
degree of engagement with and interest in the subject.
C level (55-67%) - Adequate Work
Suggests that there is generally adequate quality throughout your work with several problems of
some significance. Fair comprehension of lecture material with a very few to no examples showing
the ability to integrate information in a clear and logical manner. Minimal degree of engagement
with and interest in the subject.
D level (50-54%) - Minimally Adequate Work, Barely at a Passing Level
Suggests serious flaws or deficits in the quality of your work with minimal comprehension of lecture
material and no ability to integrate information in a clear and logical manner. Lack of engagement
with and interest in the subject.
4
F Level (0-49%) - Failing Work
Inadequate quality of work for successful completion of the course.
The laboratory mark for biology 153 is based on:
8 Physiology Lab Reports: (8 @ 2% each; 1 @ 4%)
This includes marks for pre-lab quizzes given before every lab (except the introductory lab)
10 Anatomy quizzes: (2% each)
Total: 40%
NOTE: For Biology 153, you must pass both the lecture and lab components
to pass the course (for the Faculty of Science, a minimum of 60% is required to
pass).
Lab Preparation
Attendance in the labs is mandatory and a mark of 0% will be given for missed labs.
Late lab reports will be docked 10% per day late.
In order to gain sufficient background knowledge of the subject studied, you are expected to read the
Laboratory Exercise before arriving in the lab.
Because the lab exercises are long adequate preparation is essential for timely completion of all
assignments! In addition, IT IS NOT ACCEPTABLE to show up late at the start of a lab period, or to leave
early simply to accommodate a bus schedule!
Lab Reports
Students will work in groups of 2-4, however, separate and independent lab reports are required from each
student following all physiology labs. Plagiarism will be dealt with severely. Instructions for preparation of
lab reports are included in your Physiology Lab Manual. Each report must be handed in within one week
following completion of the lab, with your textbook and lecture notes used as references
Please read the following carefully!
It is easy to succeed in Biology 153/155, as long as you approach this course with certain degree of
maturity and proper attitude. The few points suggest some strategies that you may find helpful in
your study of the lecture material.
1. Always read available lecture notes (not just the slides), BEFORE coming to lecture.
You are responsible for the entire content of the Lecture Notes. Because there is not enough time
to discuss everything in lectures, we will concentrate on specific problems that are either more
difficult or critically important for the comprehension of the entire topic. Therefore, you MUST read
your lecture notes ahead of time in order to place each lecture in proper context.
2. Attendance is mandatory.
Not everything is written on the slides! In many instances, important information will be presented
orally in class. It is your responsibility to attend class and take comprehensive notes. As a student, I
found lectures where the instructor simply read the slides verbatim to be boring. As a lecturer, it is
5
even more so. Therefore, so that neither you, nor I, fall asleep I will present a significant portion of
the material verbally.
3. Study consistently.
DO NOT wait with studying until last 48 hrs before the exam! The amount of information will
overwhelm you, we guarantee it! It is much more effective to spend a short amount of time (even
15-20 min.) in the evening following each lecture trying to understand the material. This way you
should establish good comprehension of each individual concept and can concentrate on Aputting
the pieces together@ during 1-2 weeks before the exam.
4. Ask questions.
We tried very hard to write your Lecture Notes in a clear and easy to follow format, for the most
part they are a ‘compressed’ version of your textbook. As you read them, first concentrate on
understanding the material on its own, and then try to fit it into the context of a function of a
particular organ, a physiological system, or the entire body. However, many aspects of physiology
are complex! DO NOT HESITATE TO ASK QUESTIONS each time you run into a problem.
REMEMBER, THERE ARE NO STUPID QUESTIONS! You can see me in my office (check my
office hours), make an appointment, see one of your TAs (check their office hours) or simply talk to
other students in the class or your study group (see below) but never leave questions unanswered,
they like to show up on exams!
5. Study in small groups.
It won’t be long before you will get to know other students in the class, you may know some
already. Try to establish a small (3-4 students) study group as soon as possible. Try to get together
once a week, more often closer to each exam, to reinforce each other’s comprehension of the
material, ask and answer questions, etc. Such interactions will help you to assess your knowledge
and point the areas that you overlooked in studying on your own.
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Biology 153/155
LECTURE OUTLINE Fall Term 2018/19
Topics covered
Introduction: Basic review of vertebrate and human evolution. Basic chemistry review
Cell Structure and organelle function
Nervous System: Organization of Nervous Tissue. Resting Membrane Potentials and Graded Potentials.
Action Potentials; Ionic basis of Action Potential, channel cycling and refractory periods. Propagation
of
Action Potentials. Synapses and synaptic transmission; Integration at Postsynaptic Membranes. Neural
Integration; Neuronal Circuits. Special senses.
Skeletal Muscle: Microanatomy. Mechanism of Contraction. Contraction in Whole Muscles. Factors
Affecting the Force of Contraction. Reflex Activity.
Endocrine System: Overview; Hormones. Mechanisms of Hormone Action. The Pituitary Gland and
Its
Hormones. The Thyroid and Parathyroid Glands. The Adrenal Gland., The Endocrine Pancreas.
Reproductive System: Determination of Sex. Sexual Development. Endocrinology of Male
Reproduction. Endocrinology of the Ovarian cycle. Fertilization and Pregnancy. Endocrinology of
Pregnancy. Labour and Delivery Cycle.
Review (Time permitting)
End of Term 1
Important Dates:
Sept 21 Last day to drop course without a W
Nov 23 Last day to withdraw from course with a W
MIDTERM EXAM: October 25 (Both Sections)
7
Biology 153/155
LECTURE OUTLINE Winter Term 2018/19
Topics covered
Cardiovascular System: Heart Physiology. Cardiac Action Potential and Cardiac Contraction.
Conduction Pathway and Pacemaker Cells. Cardiac Cycle and Cardiac Output. Regulation of Cardiac
Output. Control of Blood Pressure.
Physiology of the Circulation: Physical Principles of Blood Flow. Capillary Exchange
Control of Tissue Blood Flow. Short Term Regulation of Blood Pressure.
Blood: Composition of blood. Blood types. White blood cells and Red blood cells.
Immunology: The lymphatic system, Inflammation. Innate and Acquired immunity. Lymphocyte
development and selection. Vaccines.
Respiratory System: Mechanics of Breathing. Boyle's Law and Pulmonary Ventilation. Airway
Resistance and Breathing. Gas Exchanges Between the Blood, Lungs, and Somatic Tissues.
Transport of Oxygen and CO2 by Blood. Role of Respiration on Blood pH.
Digestive System: Regulation of Gastric Secretion. Gastric Motility and Emptying. Role of the
Small
and Large Intestines in Digestion. Chemical Digestion and Absorption, Metabolic Evens of the
Absorptive State. Role of the Liver in Metabolism
Urinary System: General anatomy of the kidney. Glomerular Filtration. Regulation of Glomerular
Filtration. Tubular Re-absorption. Regulation of Urine Concentration and Volume. Creation and Role
of the Medullary Osmotic Gradient. Electrolyte regulation.
HIV Lecture by Dr. M. Harris
End of Term 2
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LABORATORY OUTLINE Winter Term 2018/19
Lab Date Topic
(week ) Date/Lab
Sept. 3 No Labs
1 10 Introduction and Histology
2 17 Cell Permeability
3 24 Surface Anatomy
4 Oct. 1 Spinal Cord, Spinal Nerves, and the Autonomic Nervous System
5 No labs this week
6 15 Physiology of the eye and Special Senses
7 22 Joints and Body Movement
8 29 Muscle Physiology
9 Nov. 5 Muscle Reflex Physiology
10 12 No labs this week
11 19 Gross Anatomy of the Muscular System
12 26 Gross Anatomy of the Muscular System (cont.)
Winter Break
13 Jan. 2 No labs this week
14 7 Human Vascular System
15 14 Cardiovascular Physiology
16 21 Blood
17 28 Lymphatic System Anatomy
18 Feb. 4 Respiratory Anatomy
19 18 No labs this week
21 25 Physiology of the Respiratory System
22 Mar. 5 Anatomy of the Digestive System
23 11 The Digestive Physiology
24 18 Anatomy of the Renal System
25 25 Renal Physiology

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