BIO130H1

Molecular and Cell Biology

University of Toronto St. George

One of the goals of modern biology is to understand how the basic building blocks of life give rise to biological form and function. This course provides students with a common lexicon to understand the key principles and concepts in molecular and cell biology, with a focus on how the building blocks of life lead to functioning cells. (Lab Materials Fee: $10). Lab coat and safety glasses are required for use in laboratories; students are responsible for purchasing these items (approximate cost is $25).
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BIO130H1 Study Guide - Fall 2018, Quiz - Helicase, Alpha Helix, C-Peptide
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TEXTBOOK QUIZ #1 1. A group of molecular cell biologists are attempting to synthesize a compound to minis the effects of a well-known hormone that affects digestion. They would like your advice about how to go ab...

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BIO130H1
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BIO130H1 Study Guide - Fall 2018, Midterm - Cycloheximide, Chloroplast Dna, Metabolome
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1. Which of the following correlates the most with genome size? a. An organisms size. b. The number of repeated sequences. c. An organisms complexity. d. The number of genes encoding proteins....

Biology
BIO130H1
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BIO130H1 Study Guide - Fall 2018, Midterm - Rna Polymerase Ii, Cleavage And Polyadenylation Specificity Factor, Viral Vector
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1. The following statements describe different aspects of mRNA processing and maturation in the nucleus of eukaryotic cells. Which of these statements is FALSE? a. The first step in capping the 5 end of mRNAs is to...

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BIO130H1
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All BIO130H1 Materials | Winter 2019

BIO130H1 Lecture Notes - Winter 2019, Lecture 26 - Spindle Apparatus, Cell Division, Kinetochore
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find more resources at oneclass.com BIO130 Lecture 26 03/04/2019 Metaphase All chromosomes are aligned o On the metaphase plate Microtubules from opposite poles: o Are attached to kin...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 25 - Gene Duplication, G1 Phase, G2 Phase
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find more resources at oneclass.com BIO130 Lecture 25 01/04/2019 The cell cycle M phase: o The nucleus and cytoplasm divide Mitosis Cytokinesis Interphas...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Study Guide - Winter 2019, Final - Lipid Bilayer, Membrane Lipids, Signal Transduction
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find more resources at oneclass.com LECTURES 1 4 1. CELLULAR MEMBRANES Introduction to the plasma membrane Membrane functions: 1. Compartmentalization allows specialized activit...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 24 - Basal Lamina, Connective Tissue, Plant Cell
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BIO130 Lecture 24 28032019 Plant cell wall Plant cells produce and deposited their cell wall More rigid than the ECM of animal tissue Composed of o Cellulose o Pectin Plasmodesmata Junctions between plant cells Cells shari...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture 23: Junctions
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BIO130 Lecture 23 25032019 Types of junctions Anchoring junctions All present in epithelial cells Occluding junctions (first two hold the sheet of cells together) Channel-forming junctions Signal-relaying junctions Remembe...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 22 - Intermediate Filament, Axon Terminal, Endomembrane System
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BIO130 Lecture 22 21032019 Nerve cells These neurons in the arm can be a meter long Problem: o How does neurotransmitter synthesized in the ER get to the synapse? o Neurotransmitters are secreted via vesicles to the axon t...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 21 - Fluorescence Microscope, Intermediate Filament, Electron Microscope
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find more resources at oneclass.com BIO130 Lecture 21 18/03/2019 3 types of filaments form the cytoskeleton Microfilaments o Made of actin o Diameter: 5-9nm o Look like two smal...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 20 - Nuclear Pore, Transmembrane Protein, Translocon
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find more resources at oneclass.com BIO130 Lecture 20 14/03/19 Protein sorting mechanisms Gated o Proteins move between the cytosol and nucleus through NPCs o NPC = nuclear pore complex ...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 19 - Exocytosis, Endocytosis, Nucleolus
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BIO130 Lecture 19 11032019 Definition: organelle A subcellular compartment or large macromolecular complex, often membrane-enclosed, that has a distinct structure, composition and function Examples of membrane-enclosed org...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 18 - Electrochemical Gradient, Symporter, Uniporter
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BIO130 Lecture 18 06032019 Na+glucose symporter and Na+H+ exchanger These two transporters use the energy stored in the Na+ electrochemical gradient to move other molecules against their electrochemical gradient Continued ...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 17 - Resting Potential, Electrochemical Gradient, Passive Transport
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BIO130 Lecture 17 04032019 Proteins involved in membrane transport Multipass transmembrane proteins: o Create a protein-lined path across cell membrane o Transport polar and charged molecules o Ions, sugars, amino acids, n...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 16 - Cytosol, Lipid Bilayer, X-Ray Crystallography
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BIO130 Lecture 16 280219 Cystolic and exoplasmic face leaflet of the lipid bilayer Golgi bulges out and forms a vesicle, the leaflets stay consistent (no flip-flopping) Nucleus composed of two membranes: o Inner still a cy...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture 13: Phospholipids, Fluid Mosaic Model of Membranes, Steroids & Cell Features
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BIO130 Lecture 13 25022019 Typical animal cell o Lysosome degradation of cellular components that are no longer necessary o Extracellular matrix specialized material, outside of the cell NOTE: other species have stuff outs...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Midterm: Lectures 1-12
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BIO130 NOTES (WINTER 2019) LECTURES 1 4 1. INTRODUCTION TO CELL AND MOLECULAR BIOLOGY Cell theory: o All organisms are composed of 1< cells o The cell is the structural unit of life o Cells arise from pre-existing cells Or...

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BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture 12: Translation
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find more resources at oneclass.com BIO130 Lecture 12 14/02/2019 The link between mRNA and protein sequence Adapter woks as the link between mRNA and the protein sequence being made by the ribosome ...

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BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture 11: Transcription Part II continued
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find more resources at oneclass.com BIO130 Lecture 11 11/02/19 RT-PCR Reverse Transcriptase PCR Commonly used technique You take some tissue sample Purify the mRNA Make complementary...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture 10: Transcription Part II
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find more resources at oneclass.com BIO130 Lecture 10 07/02/2019 Promoters TATA box TATA sequence is highly conserved o Found 25-36 b.p. upstream from the start site of transcription o H...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 9 - Sigma Factor, Enzyme, Phosphodiester Bond
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find more resources at oneclass.com BIO130 Lecture 9 04/02/19 Generation of an RNA Transcript: Template: single-stranded DNA (ssDNA) RNA linked by phosphodiester bonds o Polymerase facilitate...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 8 - Reverse Transcriptase, Telomerase, Dna Replication
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BIO130 Lecture 8 31012019 Telomerase to the rescue: The repetitive sequence that is added to the 3 end of the parental strand is determined by the RNA template in telomerase Its not a very long sequence but it generates G ...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 7 - Okazaki Fragments, Phosphodiester Bond, Primase
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BIO130 Lecture 7 280119 Following the action of helicase, single strand binding proteins keep DNA strands separated Once one of the DNA binding proteins is attached, it attracts other DNA binding proteins o Separates the s...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture 6: Packaging of Nucleosomes & DNA Replication
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find more resources at oneclass.com BIO130 Lecture 6 24/01/19 Packaging of nucleosomes: Cohesion is involved in forming chromatin loops Loops may be attached to a nuclear scaffold to enable increased co...

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BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 5 - Hybridization Probe, Rubber Band, Nucleoid
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BIO130 Lecture 5 210119 The Human Genome: Its divided into 50 unique sequences and 50 repeated sequences Only 1.5 of the genome encodes proteins INTRONS protein-coding regions o Part of the unique sequences TRANSPONS left ...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 1 - Endoplasmic Reticulum, Endomembrane System, Bacteria
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BIO130 Lecture 1 7012019 The Cell Theory: All organisms are composed of 1 or more cells The cell is the structural unit of life Cells arise from pre-existing cells Types of cells: Prokaryotic o Does not possess nucleus o S...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 4 - Alpha Helix, Coiled Coil, Opioid Peptide
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find more resources at oneclass.com BIO130 Lecture 4 17/01/2019 Vasopressin vs Oxytocin: Differences in primary amino acid (AA) sequence matter Both are 9 AA long Neuropeptide hormones AA s...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture Notes - Winter 2019, Lecture 3 - Dna Replication, Protein Structure, Hydrophile
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BIO130 Lecture 3 14012019 Base pairing Base pairing is said to be complementary Holds the DNA helix together A T o Forms 2 hydrogen bonds C G o Forms 3 hydrogen bonds NOTE: hydrogen bonds are weak on their own but when add...

Biology
BIO130H1
Melody Neumann, Kenneth Yip
BIO130H1 Lecture 2: Model Organisms, the Central Dogma & Nucleic Acids
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BIO130 Lecture 2 10012019 Tree of life: Phylogenetic tree used to look at evolutionary relationships Constructed based on RNA gene sequences Tree changes using different sequences Studying diversity: 19 20 century approach...

Biology
BIO130H1
Melody Neumann, Kenneth Yip

BIO130H1 Syllabus for Melody Neumann, Kenneth Yip | Winter 2019

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