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Verified Documents at University of Toronto St. George

Molecular and Cell Biology
University of Toronto St. George
Verified Notes

Browse the full collection of course materials, past exams, study guides and class notes for BIO130H1 - Molecular and Cell Biology at University of Toronto St. George verified by …

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Kenneth Yip

Melody Neumann, Kenneth Yip

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Class Notes

Taken by our most diligent verified note takers in class covering the entire semester.

BIO130H1 Lecture 1: Lectures 1 & 2

BIO130H1 Lecture Notes - Lecture 1: Endoplasmic Reticulum, Endomembrane System, Bacteria

BIO130H1 Lecture 2: Model Organisms, the Central Dogma & Nucleic Acids

Tree of life: phylogenetic tree used to look at evolutionary relationships, constructed based on rna gene sequences, tree changes using different seque

BIO130H1 Lecture Notes - Lecture 2: Adenine, Eukaryote, Pentose

BIO130H1 Lecture Notes - Lecture 3: Dna Replication, Protein Structure, Hydrophile

BIO130H1 Lecture Notes - Lecture 3: Google Images, Deoxyribonucleoside, Ribonucleoside

BIO130H1 Lecture Notes - Lecture 4: Alpha Helix, Coiled Coil, Opioid Peptide

Note: the order of the aa"s is just as important as their presence e. g. leu-enkephalin is a natural opioid peptide which down modulates the perception

BIO130H1 Lecture 5: BIO130 Lecture 5 - Protein structures and genomes

BIO130H1 Lecture 5: The human genome, histones and packaging of DNA

Bio130h, lecture 5: the human genome, histones and packaging of dna. Only 1. 5 per cent of our genes encode proteins. Intronic sequences make up a big

BIO130H1 Lecture Notes - Lecture 5: Hybridization Probe, Rubber Band, Nucleoid

It"s divided into 50% unique sequences and 50% repeated sequences: only 1. 5% of the genome encodes proteins. Introns protein-coding regions: part of t

BIO130H1 Lecture 6: Packaging of Nucleosomes & DNA Replication

Packaging of nucleosomes: cohesion is involved in forming chromatin loops, loops may be attached to a nuclear scaffold to enable increased compaction.

BIO130H1 Lecture Notes - Lecture 7: Okazaki Fragments, Phosphodiester Bond, Primase

BIO130H1 Lecture Notes - Lecture 8: Reverse Transcriptase, Telomerase, Dna Replication

Telomerase to the rescue: the repetitive sequence that is added to the 3" end of the parental strand is determined by the rna template in telomerase. I

BIO130H1 Lecture Notes - Lecture 9: Sigma Factor, Enzyme, Phosphodiester Bond

Generation of an rna transcript: template: single-stranded dna (ssdna, rna linked by phosphodiester bonds, polymerase facilitates the reaction to produ

BIO130H1 Lecture 10: Transcription Part II

BIO130H1 Lecture 11: Transcription Part II continued

BIO130H1 Lecture 12: Translation

Genetic code: ensuring fidelity: two sequential steps in ensuring fidelity, aminoacyl-trna synthetases, there is one a-trna for each amino acid, atp ne

BIO130H1 Lecture 15: Phospholipids, Fluid Mosaic Model of Membranes, Steroids & Cell Features

BIO130H1 Lecture Notes - Lecture 16: Cytosol, Lipid Bilayer, X-Ray Crystallography

Cystolic and exoplasmic face / leaflet of the lipid bilayer: golgi bulges out and forms a vesicle, the leaflets stay consistent (no flip-flopping, nucl

BIO130H1 Lecture Notes - Lecture 17: Resting Potential, Electrochemical Gradient, Passive Transport

Proteins involved in membrane transport: multipass transmembrane proteins, create a protein-lined path across cell membrane, transport polar and charge

BIO130H1 Lecture Notes - Lecture 18: Electrochemical Gradient, Symporter, Uniporter

BIO130H1 Lecture Notes - Lecture 19: Exocytosis, Endocytosis, Nucleolus

BIO130H1 Lecture Notes - Lecture 20: Nuclear Pore, Transmembrane Protein, Translocon

Internal signal sequence / internal start transfer sequence. Path of a transmembrane protein from translation to the plasma membrane: cytosol er, trans

BIO130H1 Lecture Notes - Lecture 21: Fluorescence Microscope, Intermediate Filament, Electron Microscope

3 types of filaments form the cytoskeleton: microfilaments, made of actin, diameter: 5-9nm, look like two smaller filaments twisted around each other.

BIO130H1 Lecture Notes - Lecture 22: Intermediate Filament, Axon Terminal, Endomembrane System

BIO130H1 Lecture Notes - Lecture 23: Keratin, Occludin, Adherens Junction

Types of junctions: anchoring junctions, occluding junctions, channel-forming junctions, signal-relaying junctions. All present in epithelial cells (fi

BIO130H1 Lecture Notes - Lecture 24: Basal Lamina, Connective Tissue, Plant Cell

BIO130H1 Lecture Notes - Lecture 25: Gene Duplication, G1 Phase, G2 Phase

The cell cycle: m phase, the nucleus and cytoplasm divide, mitosis, cytokinesis. Interphase: period between cell divisions, g1 phase, normal metabolism

BIO130H1 Lecture Notes - Lecture 26: Spindle Apparatus, Cell Division, Kinetochore

Metaphase: all chromosomes are aligned, on the metaphase plate, microtubules from opposite poles, are attached to kinetochores of sister chromatics, ki