PCB 3023C Lecture Notes - Lecture 28: Protein Kinase, Cell Membrane, Cell Growth

• School: FGCU
• Department: Process Biology
• Course: PCB 3023C
• Professor: Dr Yainita-Hernandez

Document Summary

Review gpcrs and last class: https://www. youtube. com/watch?v=alb45kgdpba&list=plrmelu4xpb-nggve-thjxmpi4cokn6fgo&index=88&t=0s, https://www. youtube. com/watch?v=mthluw0hwc0&list=plrmelu4xpb-nggve-thjxmpi4cokn6fgo&index=89. Receptor tyrosine kinases (rtks: receptor tyrosine kinases (rtks) are the largest class of enzyme-coupled receptors, rtks consists of receptors with a cytoplasmic domain that functions as a tyrosine protein kinase, phosphorylates particular tyrosines on specific intracellular signaling proteins. Protein kinase-associated receptors: protein kinase-associated receptors not only are receptors, but also function as kinases, signaling of these receptor kinases is transmitted through a phosphorylation cascade. Ligand binding stimulates their kinase activities: kinases are either tyrosine kinases or serine/threonine kinases, we will focus on rtks (tyrosine kinases) Rtks and cancer: abnormal cell growth, proliferation, differentiation, survival, and migration are fundamental features of a cancer cell, abnormalities in signaling via rtks and other enzyme-coupled receptors have a major role in the development of most cancers. Intracellular signaling proteins possess a specialized interaction domain: recognizes specific phosphorylated tyrosines on the receptor tails, sometimes the receptor and tyrosine kinase are two separate proteins.