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In this set of questions, you will need to be able to apply inheritance patterns of two different characters/genes. One gene is inherited in a sex-linked pattern, while the other gene is inherited through an autosomal gene.

A sex-linked gene determines a condition called glucose-6-phosphate dehydrogenase deficiency (G6PDHD) and is due to an X-linked recessive allele in humans.

An attached earlobe is dominant to a free earlobe, and is an autosomal gene.

Consider the following family history:

A man with an attached earlobe without G6PDHD marries a woman with G6PDHD with free earlobes.

The man’s father had free earlobes, as did both of the woman’s parents.

Use the family history to make predictions about the couple’s children.

Suppose the couple had a daughter without G6PDHD and attached earlobes. What is the probability that she is heterozygous for both genes genes? [ Select ] ["0", "1", "0.25", "0.5", "0.75"]
What is the probability that any son the couple has will have G6PDHD with free earlobes? [ Select ] ["0", "0.25", "0.5", "0.75", "1"]
What is the probability that any daughter that the couple has will have G6PDHD with attached earlobes? [ Select ] ["0", "0.25", "0.5", "0.75", "1"]
If the couple has a child, what is the probability that it will be a son with attached earlobes?

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Related questions

1) A sex-linked recessive allele of gene B is the subject of this problem. Assume that a man with the recessive allele marries a woman with a normal phenotype. The woman's father had the recessive allele too. What is the probability that the couple will have a daughter with the recessive phenotype?

2)Albinism is inherited as a simple recessive trait. If a woman and her husband are both heterozygous for albinism then what is the probability that their first five children will have these phenotypes? Child 1 - albino; child 2 - normal; child 3 - normal; child 4 - albino; child 5 - normal?

3)Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked recessive gene in humans. A woman whose father suffered from G6PD marries a normal man. (a) What proportion of their sons is expected to be G6PD? (b) If the husband were G6PD deficient would you change your answer in part (a)?

When someone is said to have inherited a predisposition to cancer, what is meant by that?

There is a germ-line mutation

The gene involved shows incomplete penetrance

The disorder has variable expressivity

There is a somatic mutation

Imagine you observe the following in a data set: more males affected than females; approximately half the grandsons of affected males are affected; some females are affected but usually only if their maternal grandfather was affected and their mother married an affected male. What type of inheritance might you suspect?

sex-linked recessive

autosomal dominant,sex-limited

sex-linked dominant

recessive epistasis

A cross of fruit flies was conducted. White-eyed males were cross with pink-eyed females. All F1 flies had normal eye color. F1’s were intercrossed yielding F2 flies as follows: 890 wildtype females, 455 wildtype males, 605 white-eyed males, 140 pink-eyed males, and 310 pink-eyed females. Give a genetic explanation consistent with these data.

white is autosomal recessive and epistatic to pink

pink is autosomal recessive and dominant over white

pink and white are x-linked recessive with white dominant to pink

white is x-lined recessive, pink is autosomal recessive; white is recessive epistatic to pink

An avid gardener decides to plant seeds from disk-shaped squashes she raised during the previous summer. To her surprise, 89 of her plants bear disk-shaped squashes while 61 plants produce spherical squashes and 10 produced elongate shaped squash. What is the mode of inheritance of fruit shape in these squash?

Codominance

Recessive epistasis

Duplicate interaction

Epistasis

Based on what you know about translation, what does “reverse translation” mean?

Determining a DNA sequence from an amino acid sequence

Determining a RNA sequence from a DNA sequence

Translating in the 3’ to 5’ direction

Transcribing first, then translating

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