🏷️ LIMITED TIME OFFER: GET 20% OFF GRADE+ YEARLY SUBSCRIPTION →
Log in
Biology
1
answer
0
watching
56
views
27 Jun 2018

Sequence-specific transcription factors have several domains that are required for function. What domain binds to the basal transcription machinery?

Select one:

a. it functions as a dimer

b. regulatory domain

c. transactivation domain

d. DNA binding domain

e. dimerization domain

Watch
1
answer
0
watching
56
views

For unlimited access to Homework Help, a Homework+ subscription is required.

Jarrod Robel
Jarrod RobelLv2
28 Jun 2018

Unlock all answers

Get 1 free homework help answer.
Already have an account? Log in
Share

Related textbook solutions

Molecular Cell Biology
8 Edition,
Lodish
ISBN: 9781464183393
Biology: Science for Life with Physiology
6 Edition,
Belk
ISBN: 9780134555430
Biology
2nd Edition, 2013
Openstax
ISBN: 9781947172517
Concepts of Biology
OER Edition,
Openstax
ISBN: 9781938168116
Essentials of Biology
5 Edition,
Mader
ISBN: 9781259660269

Related questions

17. Which histone is required to compact the “beads on a string” chromatin into higher-order chromatin structures such as the 30 nm fiber?

18. Certain lysine amino acids (K’s) in the core histone tail can be acetylated. How would this chemical modification of the nucleosome affect the transcription of a gene?

19. Certain protein/protein complexes do not bind DNA, but regulate processes such as transcription and replication. These proteins can associate with the chromatin by recognizing chemical modifications in the core histone tails of the nucleosome. This process represents the “histone code”. Separately, a protein that folds into its three-dimensional functional structures can have different domains with different functions. Assume that a certain protein that increases transcription does not recognize a specific DNA sequence, but rather associates with acetylated lysine amino acids in the histone tails. What domain in this protein would allow it to associate with these acetylated lysine amino acids?

1. Bacterial transcription termination VS. Eukaryotic transcription initiation

a. What is required for Rho-independent termination? How does each sequence feature contribute to the mechanism of termination?

b. What is required for Rho-dependent termination?

c. How does Rho differ from other helicases we discussed in Chapter 28? How is it similar?

d. Do you understand the difference between core promoter elements and regulatory elements? Do you understand the difference between core transcription factors and regulatory transcription factors?

e. What are the major features of the TATA-binding protein-DNA interaction? How does this interaction lead to dsDNA destabilization?

2. The receptor that binds the steroid hormone testosterone is located in the cytoplasm of its target cells. Vasopressin is a peptide hormone (nine amino acids long) that stimulates water reabsorption in the kidney. Its receptor is an integral protein in which the domain of the receptor responsible for binding vasopressin is located on the extracellular side of the cell membrane.

a) Why must the vasopressin-binding domain of the vasopressin receptor be located on the outside of a cell while the testosterone receptor can be located within a cell? Neither hormone binds to another molecule before it binds to its receptor. (If you are curious, the vasopressin sequence is Gly-Arg-Pro-Cys-Asn-Gln-Phe-Tyr-Cys – you can look up those side chains if you want.)

b) What type or types of amino acids do you expect to predominate in the vasopressin-binding domain of the vasopressin receptor? What type or types of amino acids do you expect to find the transmembrane region of the vasopressin receptor (this region has several alpha helices passing through the membrane)? Explain your reasoning.

c) Why are alpha-helices commonly found in the transmembrane region of integral proteins?

Related Documents

BIO230H1 Lecture Notes - Lecture 4: Dna-Binding Domain, Rna Polymerase Ii, Eukaryotic Transcription
cerisetoad631
BIO 198 Lecture Notes - Lecture 14: Stem-Loop, Regulatory Sequence, Antitermination
silverbee937
BIO120H1 Lecture Notes - Lecture 11: Plasmid, Dna-Binding Domain, Tryptophan
lemongnu935

Weekly leaderboard

Home
Homework Help 3,900,000
Biology 460,000
Start filling in the gaps now
Log in