The following data was obtained from a patient received IV bolus of 300 mg of drug X.
Time interval of urine
collection (hr)
Volume of urine
collected (mL)
Drug concentration in urine (mg/mL)
0-2
75.0
585.3
2-6
30.0
2315.5
6-8
114.0
239.6
8-10
120.0
194.3
10-12
100.0
199.0
12-24
687.0
103.6
24-48
2650.0
14.4
48-72
2012.0
3.3
From this data, determine the following:
Is the drug being solely removed by renal excretion in an unchanged form or is it undergoing metabolism as well?
The elimination rate constant (K) as well as the excretion (Ku) and metabolism rate (Km) constants (in case it is undergoing metabolism)
The cumulative amount of drug eliminated (Xu) in the urine at 15 h following the administration of the aforementioned dose.
The amount remaining in the body after 36 hours
The following data was obtained from a patient received IV bolus of 300 mg of drug X.
| Time interval of urine collection (hr) | Volume of urine collected (mL) | Drug concentration in urine (mg/mL) |
| 0-2 | 75.0 | 585.3 |
| 2-6 | 30.0 | 2315.5 |
| 6-8 | 114.0 | 239.6 |
| 8-10 | 120.0 | 194.3 |
| 10-12 | 100.0 | 199.0 |
| 12-24 | 687.0 | 103.6 |
| 24-48 | 2650.0 | 14.4 |
| 48-72 | 2012.0 | 3.3 |
From this data, determine the following:
Is the drug being solely removed by renal excretion in an unchanged form or is it undergoing metabolism as well?
The elimination rate constant (K) as well as the excretion (Ku) and metabolism rate (Km) constants (in case it is undergoing metabolism)
The cumulative amount of drug eliminated (Xu) in the urine at 15 h following the administration of the aforementioned dose.
The amount remaining in the body after 36 hours
