Question

Can someone please help me with the 2 questions below! I'm notunderstanding at all and can you explain how you got your answer soI can understand. Thank you in advance! :)

1. Epidermal Growth Factor is a protein that binds its receptorwith high affinity (low Kd). Choose the most likely order of eventsfor what ensues:

• A) G protein activation> tyrosine kinase activity>transcription factors active> map kinase activation and signalamplification
• B) G protein activation and signal amplification > mapkinase activation >transcription factors active>tyrosinekinase activity
• C) tyrosine kinase activity>G protein activation> mapkinase activation and signal amplification>transcription factorsactive
• D) tyrosine kinase activity>Gprotein activation> phosphatase activation> secondmessengers>map kinase activation >transcription factorsactive

2. Epidermal Growth Factor (EGF) levels eventually dissipate andthe cellular response (gene transcription and translation) stops.Which of the following is not a possible reason for a cancer cellto have an inappropriate EGF pathway response:

A) mutation in an EGF receptor gene

B) mutation in a ras gene

C) mutation in a gene coding for a kinase

D) mutation in a gene coding for a second messenger