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jadepig363Lv1
28 Sep 2019
- As you continue on in your career, you become keenly interested inthe mechanisms of immune cell recruitment during the innate immuneresponse. After years of graduate work, you discovered a newcytokine (X), which chemoattracts neutrophils. In your excitementyou begin devising experiments to characterize the function andrelevance of cytokine X. (30 pts)
- From what you know of chemokines, predict the general structure ofchemokine X and its cognate receptor.
- Where, by what cell types, and when would you expect it to beexpressed? Explain, experimentally, how you would test yourhypothesis.
- What is the effect of expression of chemokine X on the immuneresponse. Explain, experimentally, how you would test yourhypothesis.
- As you are working in the lab, you obtain a major career-definingresult. You have discovered a new TLR (TLR15), which recognizeseither a bacterial or viral antigen. Your task to finish graduateschool is to fully characterize the molecule. (30 pts)
- Design an experiment to determine if your new TLR15 recognizes abacteria or a virus. What results do you anticipate and whatexperimental difficulties will you potentiallyencounter?
- Comment on the likely structure for the molecule and indicate aplausible signaling pathway for cellular activation.
- Where in the cell would you expect to find this new TLR? Why?Please design and fully explain two different experiments to testyour hypothesis.
- What are the consequences of deficiency of TLR15? Please design andfully explain two different experiments to test yourhypothesis.
- As you continue on in your career, you become keenly interested inthe mechanisms of immune cell recruitment during the innate immuneresponse. After years of graduate work, you discovered a newcytokine (X), which chemoattracts neutrophils. In your excitementyou begin devising experiments to characterize the function andrelevance of cytokine X. (30 pts)
- From what you know of chemokines, predict the general structure ofchemokine X and its cognate receptor.
- Where, by what cell types, and when would you expect it to beexpressed? Explain, experimentally, how you would test yourhypothesis.
- What is the effect of expression of chemokine X on the immuneresponse. Explain, experimentally, how you would test yourhypothesis.
- As you are working in the lab, you obtain a major career-definingresult. You have discovered a new TLR (TLR15), which recognizeseither a bacterial or viral antigen. Your task to finish graduateschool is to fully characterize the molecule. (30 pts)
- Design an experiment to determine if your new TLR15 recognizes abacteria or a virus. What results do you anticipate and whatexperimental difficulties will you potentiallyencounter?
- Comment on the likely structure for the molecule and indicate aplausible signaling pathway for cellular activation.
- Where in the cell would you expect to find this new TLR? Why?Please design and fully explain two different experiments to testyour hypothesis.
- What are the consequences of deficiency of TLR15? Please design andfully explain two different experiments to test yourhypothesis.
lalithashwin156Lv10
8 May 2023
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Trinidad TremblayLv2
28 Sep 2019
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