What is phosphorylation and why is it important?
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What is phosphorylation and how is it important?
1. When a growth factor binds to a receptor tyrosine kinase, the receptor becomes phosphorylated on tyrosine residues.
a. How does this occur?
b. Why is this phosphorylation important in initiating an intracellular signaling cascade?
c. Why does phosphorylation change the activity of proteins? (What happens to the protein physically when it is phosphorylated?)