One of your colleagues, Margaret, tells you about her medical situation one day in the lab. She states that she recently went to the doctor because she has been gaining substantial amounts of weight and she canât figure out why. She also feels like she never has enough energy (severe exhaustion). She has tried to lose the weight by exercising, but claims that her âmuscles hurtâ every time she tries to do so. Her doctor runs some tests and determines that Margaret has a mutation in isocitrate dehydrogenase, which is an enzyme that functions in the citric acid cycle. This mutation results in a non-functional enzyme, and as a result, the citric acid cycle functions at a very low rate.
Margaret then tells the doctor that she really wants to lose weight, and as heard of a compound called dinitrophenol (DNP). The doctor then explains to Margaret that DNP is extremely unsafe. He explains that the compound has been found to cause some patients to become very sick and die. He tries to explain that DNP uncouples the chemiosmotic machinery by making the lipid bilayer of the inner mitochondrial membrane leaky to H+. How exactly does DNP affect the body? What is it doing? What metabolic fucntions are being affected by this compound?
One of your colleagues, Margaret, tells you about her medical situation one day in the lab. She states that she recently went to the doctor because she has been gaining substantial amounts of weight and she canât figure out why. She also feels like she never has enough energy (severe exhaustion). She has tried to lose the weight by exercising, but claims that her âmuscles hurtâ every time she tries to do so. Her doctor runs some tests and determines that Margaret has a mutation in isocitrate dehydrogenase, which is an enzyme that functions in the citric acid cycle. This mutation results in a non-functional enzyme, and as a result, the citric acid cycle functions at a very low rate.
Margaret then tells the doctor that she really wants to lose weight, and as heard of a compound called dinitrophenol (DNP). The doctor then explains to Margaret that DNP is extremely unsafe. He explains that the compound has been found to cause some patients to become very sick and die. He tries to explain that DNP uncouples the chemiosmotic machinery by making the lipid bilayer of the inner mitochondrial membrane leaky to H+. How exactly does DNP affect the body? What is it doing? What metabolic fucntions are being affected by this compound?
