when using quantitative trait loci mapping, why is it significant to find linkage between a trait of interest and a genetic marker?

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Jarrod RobelLv2

28 Sep 2019

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Question 1: Why are marker alleles useful to study even though they do not actually affect the traits being studied? Explain in your own words the logic underlying QTL mapping.

Multiplie choice: The genetic signature of recent positive selection on a locus is ...

a)	high frequency and low linkage disequilibrium

b)	low frequency and low linkage disequilibrium

c)	high frequency and high linkage disequilibrium

d)	low frequency and high linkage disequilibrium

In lecture you were shown hybrid crosses involving 2 and 3 loci. If you were to conduct a hybrid cross with 4 loci, what would the dimensions of your Punnett square be? If the alleles were purely codominant and additive to yield a quantitative phenotypic trait, how many different phenotypic classes would you expect? Explain your reasoning. Hint: You do NOT need to actually construct a Punnett square to figure out the answer and in fact it is not recommended to construct a Punnett square. Look at the similar example of a polygenic trait with 3 loci from your online activities.

You are interested in two phenotypic traits, one has a heritability of 0.8 and the other has a heritability of 0.4. You want to find the approximate location of genes controlling these phenotypes using a linkage mapping approach. But, you only have enough grant money to do this for one trait. Which one would you have more chance of success with and why? (Hint: the equation for heritability is, H2 = VG / VP) (3 marks) â

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when using quantitative trait loci mapping, why is it significant to find linkage between a trait of interest and a genetic marker?

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