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Phenylketonuria is a recessive disease that leads to the build-up of toxic levels of the amino acid phenylalanine in the blood. Untreated phenylketonuria results in a variety of symptoms, including intellectual disability. However, phenylketonuria can be effectively treated with a low-phenylalanine diet.

Bill and Bob are brothers. Their mother has phenylketonuria.

Bill marries a woman with phenylketonuria. What is the probability that they have a child with phenylketonuria?

Bob marries a woman whose father has phenylketonuria. What is the probability that they have a child with phenylketonuria?

PLease show me how you drew this and got the answer. Thanks in advance.

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Beverley Smith
Beverley SmithLv2
28 Sep 2019
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Related questions

1.In humans, PKU is an inherited metabolic disease, which if untreated leads to death at about the age of six. It is inherited as a recessive trait. What is the probability that two heterozygous parents will have:

a)a PKU child?

b)A heterozygous child?

c)A homozygous non-PKU child?

Explain your answer.

2.Unattached earlobes are inherited as a dominant trait; attached earlobes a recessive trait. Suppose a homozygous man with unattached earlobes marries a homozygous woman has attached earlobes:

a)What type of earlobes will their children have?

b)If these children marry someone with the same genotype as themselves, will all of their children have attached lobes?

Explain your answer.

2. Familial incontinentia pigmenti (IP) is an X-linked dominant disorder that causes a disturbance of skin pigmentation and can be associated with malformations of the eyes, teeth. and skeleton. The disorder is most often lethal prenatally in males.

a. If a woman who exhibits IP marries a man with no family history of the disease, what is the probability that they will have a child with the disease? Please explain how you determine this probability (3 points)

b. Continuing with the previous problem, the couple's first child is a girl who does not exhibit this disorder. Given that the mother has the disorder, the couple is quite informed about the disorder. After the ultrasound of their second child, they are told that they are expecting a boy. The couple is quite concerned that the woman will not be able to carry the baby to term. However, she is able to give birth to a baby boy. After a week, the couple starts to notice symptoms of IP on the skin of their baby boy. The couple is concerned that their son might die soon. This does not happen. The child is currently two years of age and does not suffer from the disorder. How is this possible? Please explain in 3-4 sentences based upon topics being covered for this exam. (3 points)

Questions 4-6. Sickle cell disease:
Sickle cell disease (sickle cell anemia) is a relatively common disorder in individuals of

African descent and affects approximately 1 in 500 African-Americans. Due to a mutation in an autosomal gene for hemoglobin, the homozygous recessive genotype leads to red blood cells that are relatively stiff and sticky, and deform into a sickle shape as they lose oxygen. This leads to problems in the spleen, and anemia.

There are hundreds of different hemoglobin alleles. Individuals heterozygous for the sickle cell allele and one non-sickle cell allele usually do not experience major complications or even noticeable symptoms. A genetic test is available to diagnose carriers.

James does not have sickle cell disease, neither does his mother or father, but his sister does. His wife Natasha does not have sickle cell disease, and neither of her parents does either. Natasha also has a sister who has sickle cell anemia and two brothers without the disease.

5.) If James and Natasha have a child, what is the probability that the child would be a homozygote for the recessive allele and have sickle cell disease? You may draw the Punnet square but please solve the problem using probability calculations, then explain your reasoning in 2-5 complete sentences.

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