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HIV/AIDS in Society • The human immune system has several components and works well to protect us from disease. How then, do we explain illness? • We know that specific antibodies are created in response to specific antigens. Antibodies target and kill the invading antigens, protecting us from disease. If this is so, how would you explain why the HIV virus (an antigen) survives and is not killed by antibodies? • The HIV virus is a lentivirus. What health implications does this have for the person infected with the virus

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Beverley Smith
Beverley SmithLv2
28 Sep 2019
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QuestionGroup: #51 Innate immune 1

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Homework

51

What is the name of a chemical substance responsible for stimulating an immune response?

A

Pathogen

B

Rotomers

C

Antigen

D

Antibody

E

Troll receptor

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QuestionGroup: #52 Innate immune2

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52

What is the purpose of secondary metabolites produced by normal flora in your body?

A

To aid T cells in fighting local infection

B

To kill infected B cells

C

To help balance electrolytes

D

To inhibit adhesion, and growth of the certain microbes

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QuestionGroup: #53 Innate immune3

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Homework

53

The lysozyme removes most bacteria in our foods through the saliva in our mouth, how does it do this?

A

The lysozyme attacks the bacteria through the blood.

B

The lysozyme are not strong enough to get rid of bacteria.

C

The lysozyme breaks down the polysaccharide walls of different bacteria.

D

The lysozyme will tell your body to get rid of the bacteria by vomiting.

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QuestionGroup: #54 Adapt immune 1

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54

In adaptive immunology, the key component is which of the following?

A

Antigen trigger the the production of vaccines.

B

Antibodies will trigger responses in the antigen which will cause an inflamation.

C

Antigens trigger responses of the antibodies which will recognize the antigen.

D

Antibodies will be able to recognize other antibodies and destroy them.

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QuestionGroup: #55 Adapt immune2

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55

An autoimmune induced disorder is...?

A

When the body's immune system attacks a tissue or organ in the body

B

When the immune system is not present

C

When the body attacks the antigens and antibodies of the immune system

D

When the autonomic nervous system attacks the antigen and antibodies of the immune system

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QuestionGroup: #56 Adapt immune3

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56

Antibodies are also called immunoglobulins and constitute part of the blood proteins. How do antibodies work?

A

Agglutination-- they just clump with each other (blocking antigen)

B

Precipitation-- force insolubility and settled out of solution along with antigens

C

Complement fixation-- proteins attach to antigen surface (causing cell lysis)

D

Neutralization-- bind to specific sites to prevent antigen attachment

E

All of the above

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QuestionGroup: #57 Infectious disease

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57

The most deadly STD is HIV, but many other viruses can be deadly. Name the most common sexually transmitted infection.

A

Genital human parisis virus (GHPV)

B

Herpes Simplex

C

Human papilloma virus (HPV)

D

Human pappathe virus tentis (HPVT)

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QuestionGroup: #58 Infectious disease2

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58

Microbes have developed an array of weapons to be able to go from host to host. These virulent factors are divided into several groups, but one important group is the one produced by bacteria. Name the subgroups within this bacterial group.

A

Retretoxin and maitotoxin

B

Retretoxin and butotoxin

C

Endotoxins and exotoxins

D

Lipotoxin and exotoxin

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QuestionGroup: #59 Infectious disease3

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59

Sexually transmitted diseases are very successful at spreading from one person to another. Name one important reason for this fact.

A

Mucous membranes use B cells only and are resistant to antigens

B

Mucous membranes in the sex organs differ from those of the skin in that they allow certain pathogens into the body

C

STDs are transmitted through sex only

D

STDs are usually caused by viruses

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QuestionGroup: #60 HIV/ AIDS

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60

HIV has which of the following characteristics?

A

It has an enzyme called reverse transcriptase which causes the DNA to reverse the nucleotide sequence in messenger RNA.

B

It is a retrovirus meaning that it reverses the order of protein production in that the virus affects the DNA in the cell to make the protein.

C

It is an anti-retrovirus meaning that it attacks the DNA causing the development of new HIV particles.

D

It has a short incubation period which means that the symptoms show up also immediately after infection.

Topic A

1. Indicate to which branch(es) of theimmune system the following statements apply.

Explain your answer.

a) Involves macrophages

b) Responds to viral infection

c) Involves T cells

d) Responds to bacterial toxins

e) Most likely responds following an organ transplant

f) Involves cytotoxic T cells

g) Involves B cells

h) Involves complement

i) Responds to extracellular bacterial infection

j) Involves secreted antibody

k) Kills virus infected self cells

I) Involves the thymus

m) Involves the bone marrow

2. You are given two solutions, one containing protein A and theother the antibody to this protein both at about 5mg/ml. When youadd 1 ml of anti-A to 1 ml of protein A, a precipitate forms.However, when you dilute the antibody solution 20 fold and then mix1 ml of the diluted anti-A with 1 ml protein A, no precipitateforms.

Explain why no precipitate formed with the diluted antibody.

3. An energetic immunology student has isolated protein X.

The student believes it is a new isotype of humanimmunoglobulin.

a)What structural features would protein X have to have in orderto be classified as an immunoglobulin?

b) You prepare rabbit antibodies to (i) whole human IgG, (ii) tohuman λ chain and (iii) to human γ chain.

Assuming protein X is in fact a new immunoglobulin isotype,which of these antibodies will bind to protein X? Explain why?

TOPIC B

4. a) Describe the time course of a typical antibody response totetanus toxoid

b) Outline a vaccination schedule that makes effective use ofthis information.

5. a) Tetanus immunoglobulin from the horse can be used toprotect an individual against tetanus. How is the treatmentadministered and what are the advantages/disadvantages of this formof immunisation? 2

b) Is it possible to confer cell mediated immunity on anunsensitised recipient by transferring cells?

c) Would this be a practical method of immunisation, and whatproblems may be encountered in this type of experiment?

6. If you inject a rabbit with a large protein antigen X andsubsequently harvest the antiserum from the animal, would youexpect the antibodies to X in the antiserum to be monoclonal orpolyclonal?

TOPIC C

7. a) Why, if the immune system is so efficient, do we continueto suffer from infectious diseases?

b) Speculate on the consequences if the immune system were tolose its ability to distinguish self-antigens from foreignones.

c) If a child is born without a thymus gland, what will be thenature of the child's illness

d) If a child were born with a defect in the complement system,say a deficiency in function C3, what would be theconsequences?

8 Considering only combinational joining of gene segments andassociation of light and heavy chains, how many different antibodymolecules potentially could be generated from germ line DNAcontaining 500VL and 4JL gene segments and 200VH. 10DH and 4JH genesegments?

9 During an immune response to antigen, the antibodies producedduring a secondary and subsequent responses have a greater affinityfor antigen than those produced during a primary response toantigen

Explain what is meant by "affinity"

Explain in principle the mechanism which explains the aboveobservation re increasing antibody affinity for antigen insecondary and subsequent responses

1) What is the most efficient and cost-effective way to control infectious diseases? A) variolation C) passive immunotherapy using immunoglobulins B) active immunization by vaccination D) immune testing E) autoimmunization 2) Variolation was first used _______ A) to immunize the Chinese against smallpox. B) to protect individuals against the plague during the Middle Ages. C) to spread smallpox throughout the Native American populations. D) to treat individuals exposed to hepatitis. E) for research purposes in the 20th century. 3) Almost a century after Edward Jenner introduced successful vaccination, Louis Pasteur developed vaccine(s) against A) anthrax. B) human cholera. C) rabies. D) influenza. E) both anthrax and rabies. 4) Pathogens may be attenuated for use in vaccines by ______ A) raising the pathogen for several generations in tissue culture cells. B) genetic manipulation. C) treatment with formaldehyde. D) genetic manipulation coupled with treatment with formaldehyde. E) genetic manipulation and/or raising the pathogen for several generations in tissue culture cells. 5) Which of the following statements regarding an inactivated vaccine is FALSE? A) It can be produced with deactivated whole microorganisms. B) It can be produced from antigenic fragments of a pathogen. C) It is safer than an attenuated vaccine. D) It is made from mutated forms of the pathogen. E) It is made from pathogens that cannot replicate. 6) Which of the following substances is commonly used to inactivate microbes before using them for vaccination? A) formaldehyde B) aluminum C) mineral oil D) saponin E) aluminum phosphate 7) What type of vaccine is the hepatitis B vaccine? A) inactivated whole pathogen B) attenuated vaccine C) toxoid vaccine D) a recombinant vaccine composed of a single antigen of the hepatitis virus E) a vaccine produced by treating the virus with formaldehyde 8) An infectious disease researcher isolates the pathogen responsible for an emerging disease. The microbe is grown in the lab for many generations. A preparation of the laboratory-grown microbe is treated with ionizing radiation and then tested for its potential as a vaccine. What type of vaccine is this? A) attenuated B) subunit C) combination D) toxoid E) inactivated whole 9) OPV, the attenuated oral poliovirus vaccine, is no longer administered in the U.S.A. because it A) is very toxic. B) does not provide good immunity. C) can revert to wild-type virulence. D) can be spread to contacts. E) can be spread to contacts and can revert to wild-type virulence. 10) Hybridomas are factories for antibodies and are produced by _____ A) combining two virus-infected cells. B) fusing plasma cells with myeloma cells. C) repeated culture of a pathogen until it loses its virulence. D) combining a viral infected cell with a bacterial infected cell. E) combining two bacterial infected cells. 11) The study and diagnosis of antigen-antibody interactions in the blood is known as _____ A) immunology. B) hematology. C) serology. D) cytology. E) histology. 12) Which type of antibody assay is represented in this figure? A) an indirect ELISA C) an indirect immunofluorescence assay B) a direct ELISA D) a western blot E) an immunodiffusion assay 13) Titration is a serological procedure that A) identifies the causative microbe of an infectious disease. B) determines the amount of an antibody in the blood. C) must be done before the western blot test to diagnose HIV. D) is used for blood grouping. E) has been replaced by genetic engineering in isolating the antigen of a pathogen. 14) A woman uses a home pregnancy test kit that tests for hCG hormone in urine. She knows this is a type of antibody assay from the kit brochure. Antibodies reacting with the hormone produce two lines on the test strip. What specific type of antibody assay does this represent? A) a direct immunofluoresence test C) an immunochromatographic assay B) a complement fixation test D) an ELISA E) a neutralization assay 15) The complement fixation test uses red blood cells as the target for complement activation. Test serum containing antibodies is combined with a known amount of antigen in a tube, and then the RBCs and antibodies against the RBCs are added. A positive result for the complement fixation test would be A) a line of precipitate near the bottom of the tube. C) loss of color in the tube. B) a cloudy solution in the tube. D) a fluorescent precipitate. E) a solution that is clear due to precipitation of RBCs.

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