1. What is the role of primary lymphoid follicles in eliminating B cells that have antigen receptors specific for soluble self antigen?

2. What is "affinity maturation"? Affinity maturation of the B cell response has been likened to a process of "Darwinian selection". Explain how so?

3. If you could produce a strain of mice in which the follicular dendritic cells of the lymphoid organs were deleted, list the differences in the humoral immune response you might expect to see.

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Sixta KovacekLv2

24 Jun 2018

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