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4 Feb 2018
You are a geneticist and through careful analysis of a large family with migraine headaches have determined that the disorder is linked to a previously cloned gene, X, which lies on chromosome 14. You set out to identify the polymorphism in gene X that confers susceptibility to migraine. You isolate DNA from a family member who suffers from migraine, amplify the DNA using gene-specific primers and polymerase chain reaction, and clone it into a plasmid. You then sequence the gene and, indeed, find a single nucleotide polymorphism that causes a missense mutation within one of the exons. Can you conclude that it is responsible for conferring susceptibility to migraine?
You are a geneticist and through careful analysis of a large family with migraine headaches have determined that the disorder is linked to a previously cloned gene, X, which lies on chromosome 14. You set out to identify the polymorphism in gene X that confers susceptibility to migraine. You isolate DNA from a family member who suffers from migraine, amplify the DNA using gene-specific primers and polymerase chain reaction, and clone it into a plasmid. You then sequence the gene and, indeed, find a single nucleotide polymorphism that causes a missense mutation within one of the exons. Can you conclude that it is responsible for conferring susceptibility to migraine?
teacherrecoLv10
28 Jul 2023
Jamar FerryLv2
5 Feb 2018
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