Question

In most cases of sickle-cell anemia, where the 6th amino acid (typically glutamate) is replaced by valine, how would the potential for chemical interactions change? (You may need to look up the structures in your textbook or online).

A. Valine will form fewer covalent bonds in the protein backbone.

B. Valine will form fewer ionic bonds with other side-chains

C. Valine will form fewer hydrophobic interactions with other side-chains

D. Nothing will change because valine and glutamate have very similar chemical properties