Please help to check if the following DNA repair description is correct. if not, please help to correct. thanks!!
1. Base Excision Repair
DNA plycosylase comes in and removes deaminated C Uracil. AP endonuclease recognizes the missing tooth created by DNA glysosylase and it removes the sugar while phosphodiesterase removes phosphate group leaving DNA helix with single nucleotide gap. DNA polymerase add new nucleotide and DNA ligase seals the nick
2. Nucleotide Excision Repair
NER uses to remove large mutation. Excision nuclease comes in and cut the pyrimidine primers in a big chunk. DNA helicase removes the big chunk. DNA polymeraze synthesize nucleotides and DNA ligase seals the nick.
3. Nonhomologous end joining
The overhangs ends is recognized by Ku heterodimers and they attach to the broken chromosomes end. Additional proteins attach and join covalently. Overhangs are then digested and ligase seals the nicks
4. The repair involves sister chromatids. One of the sister chromatids has double strand breaks. Exonuclease activity degrades the 5â end. The strand invasion begins by crossing over. The single strand interacts with healthy strand on sister chromatid DNA molecule. DNA polymerase synthesize missing nucleotides and ligase seals the nicks
Please help to check if the following DNA repair description is correct. if not, please help to correct. thanks!!
1. Base Excision Repair
DNA plycosylase comes in and removes deaminated C Uracil. AP endonuclease recognizes the missing tooth created by DNA glysosylase and it removes the sugar while phosphodiesterase removes phosphate group leaving DNA helix with single nucleotide gap. DNA polymerase add new nucleotide and DNA ligase seals the nick
2. Nucleotide Excision Repair
NER uses to remove large mutation. Excision nuclease comes in and cut the pyrimidine primers in a big chunk. DNA helicase removes the big chunk. DNA polymeraze synthesize nucleotides and DNA ligase seals the nick.
3. Nonhomologous end joining
The overhangs ends is recognized by Ku heterodimers and they attach to the broken chromosomes end. Additional proteins attach and join covalently. Overhangs are then digested and ligase seals the nicks
4. The repair involves sister chromatids. One of the sister chromatids has double strand breaks. Exonuclease activity degrades the 5â end. The strand invasion begins by crossing over. The single strand interacts with healthy strand on sister chromatid DNA molecule. DNA polymerase synthesize missing nucleotides and ligase seals the nicks
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