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Biology
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11 Dec 2019

If a mismatched base is not corrected directly by DNApolymerase, which of the following would be used to correct a point mutation?

Base excision repair

Nucleotide excision repair

Non-homologous end-joining

This type of error can to be recognized or corrected.

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Keith Leannon
Keith LeannonLv2
13 Dec 2019
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Related questions

1. Why it is not necessary for Okazaki fragment to function if DNA polymerase could add nucleotides to the 5' end of a nucleotic chain?

2. "Nucleotide excision repair detects and repair single mismatches". Why this statement is wrong?

3. What is the type of bond in translation?

4. What is the direction of lagging strand synthesis?

5. How is translation terminated?

12. During homologous recombination, what events are required for formation of the heteroduplex?

13. Assume that homologous recombination occurs across a region of DNA containing a wild-type and mutant allele of a particular gene. There is a single base pair change in the mutant allele as follows:

wild-type = 5’…TTGGGTA… à 5’…TTGCGTA… = mutant allele, such that the resulting dsDNA is as follows:

5’…TTGGGTA…

3’…AACGCAT…

What would be the genotype (wild-type or mutant) if base excision repair occurs on the TOP strand?

14. What term describes the process occurring above?

For the following problems match each statement below to one ofthe choices (A-E) listed below: Each should only be used once.

A.) 0 B. 1 C. 2 D. 3 E. 4

31. When nucleotide excision repair fixes a given DNA lesion,this is the number of sites/phosphodiester bonds when cleaved by anENDOnuclease.

32. The length (#of base-pairs) of the palindromic sequence thatis recognized by the DNA methylase involved in mismatch repair inE.coli (specifically, the dam methylase).

33. The length (#of nucleotides) of the tandemly-repeatedsequences that are subject to the "repeat expansions" that underlieFragile-X syndrom, Huntington disease, and sever other geneticdisorders.

34. The number of bases in DNA (among the 4 that are normallypresent) that do NOT undero tautomeric shifts.

35. For any given initial base pair, this is the number ofpossible transition mutations.

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