Homework Help for Science

Question 3:

Scenario:

 You are the lead of a forensic toxicology team and calling all the shots. You have just been given a new case, where you must try and determine if John Doe, the person you are doing an autopsy on, was the victim of foul play – a suspected poisoning. John Doe arrived at the emergency room of a hospital one day ago alive but unconscious. The following samples were collected upon admission:

• Blood (A).
• Urine (B).
• Hair (C).

After being admitted for one day (24 hours), John Doe died with no cause of death reported. John Doe’s body arrives at your facility for autopsy along with the samples A, B, and C. You further collect the following samples:

• Liver (any part) (D).
• Stomach contents (E).
• Lungs (F).
• Vitreous humor (G).
• Hair (H).
• Blood (I).
• Urine (J).

1. You only have enough time/money to process and analyze 4 of the samples (A-J). Indicate which 4 samples you would select and explain why you chose those samples (each sample has a letter associated with it (A-J); use this letter when answering the question). In your explanation you should discuss why each sample individually was chosen and any benefits there might be from the samples complementing each other. Also include in your answer the key factor that must be considered with respect to all samples (ADME) and explain how you accommodated this with your sample choices.

2. Once you have chosen your samples, you will need to perform some form of chromatography on each one before you can start to analyze them for any poison. Indicate which method of chromatography you would choose for each sample. You can use more than one method of chromatography on a single sample or use the same method on all samples – as long as you explain how that method of chromatography works and why it’s appropriate for each sample. As part of your answer, discuss if each sample would need pre-treatment before being subjected to chromatography and what the pre-treatment would be. 

3. Now that you have prepared your samples you must visualize and quantify your results using mass spectrometry. Select an ionization method for each sample that you prepared in question 2 above, describe how it works, and why it is ideal for that specific sample.

4. Describe what you need to do in question 3 above to be able to quantify your sample. 

5. What if you were presenting your mass spectrometry results in court and had a peak at an m/z of 542.3 and you stated in your findings that this corresponds to unique fentanyl analogue, which killed John Doe. Describe what additional work you must do to support this conclusion, how it works, and why it can provide definitive proof that the compound is in fact the unique fentanyl analogue. 

As a scientist working in a government lab, you have been given full control over the production of a new compound. The compound was isolated from the Eastern cypress tree, a tree which grows throughout 75% of the world and reaches maturity in 2-3 years. It was found that only the needles contain the compound of interest (shown to the right).

Choose whether you would extract from the natural source or chemically synthesize the compound. Explain and justify three reasons that support the choice you made and one reason, that is different than anything you mentioned, why your choice might not be the best – detail required in all answers. (9 marks)

WHMIS questions:

1. Where can I find hazard information?

2. What are the hazard classifications and precautions I need to take?

3. How can I protect myself from the hazards?

4. What should I do if I am exposed to the hazard?

1. In your own words, define/explain what ionization and vapourization are with respect to mass spectrometry. (2 marks)

2. Name one of the ionization methods discussed and explain, in your own words, how it works and what's involved. (4 marks)

With respect to tandem mass spectrometry, answer the following questions In your own words:

1. What is it? (1 mark)
2. How does it work? (1 mark)
3. What can it tell you that mass spectrometry can't? (1 mark)

2. In your own words, define/explain what ionization and vapourization are with respect to mass spectrometry. (2 marks)

3.Name one of the ionization methods discussed and explain, in your own words, how it works and what's involved. (4 marks)

With respect to tandem mass spectrometry, answer the following questions In your own words:

1. What is it? (1 mark)
2. How does it work? (1 mark)
3. What can it tell you that mass spectrometry can't? (1 mark)

I need to write a full description and collect a lot of information on the following components related to “Gelatin Based Biomaterial” used in tissue Engineering for Hearing Research:

1. What specific materials is the gelatin based material?

2. What are specific dimensions can be of scaffold made from gelatin based biomaterial in hearing research ?

3. what specific type of cells we’ll be using in gelatin based biomaterial for hearing research ?

I need to write a full written report for the device that I have been working on such as “SPECIAL BLOOD PRESSURE MACHINE PRODUCT THAT IS A WIRELESS, REMOTE MONITORING DEVICE THAT CONNECTS TO A SMARTPHONE APP WITH ACCURATE MEASUREMENTS”. The final report should not exceed 15 pages including drawings and references. The report should be organized as a written version of the marketing pitch that generally includes the following :

I need to include the information outlined in table 6.2.3 above in the picture where you can integrate it into the R&D section of the report. You can describe the milestones achieved in each stage of the development timeline and any challenges faced during each phase.

Remember to keep the report concise and easy to read. Use bullet points, charts, and graphics to enhance the presentation of your information. Good luck with your report!

1 Cover slide: The cover slide should include the product name, your company's logo, and any other relevant information.

2 Elevator statement: Provide a brief summary of the product, including its unique selling proposition, target audience, and benefits.

3 The clinical need: Describe the clinical need for the product and how it solves an existing problem.

4 The solution: Provide a detailed explanation of the product, including its features, benefits, and how it works.

5 The market: Describe the target market for the product and the potential size of the market.

6 Intellectual property (IP): Discuss any patents, trademarks, or copyrights related to the product.

7 R&D: Describe the research and development process for the product, including any challenges faced and how they were overcome.

8 Regulatory strategy: Outline the regulatory requirements for the product and how you plan to comply with them.

9 Clinical studies: Describe any clinical studies conducted on the product and their results.

10 Reimbursement: Explain how the product will be reimbursed and any relevant insurance coverage.

11 Business model: Describe the business model for the product, including pricing, distribution, and revenue streams.

12 Marketing and sales: Explain the marketing and sales strategy for the product, including how you plan to reach your target audience.

13 Financial information: Provide financial projections for the product, including revenue, expenses, and profit margins.

14 Exit scenarios: Discuss potential exit scenarios for the product, such as acquisition or IPO.

15 The ask: Outline any funding needs for the product and how the funds will be used.

16 Management team: Introduce the management team and their relevant experience.

17 Closing slide: Include a closing slide that summarizes the key points of the report.

18 Appendix: Include any additional information that supports the report, such as technical specifications, drawings, or references.

I need to create a final written report for the device that I have been working on such as “SPECIAL BLOOD PRESSURE MACHINE PRODUCT THAT IS A WIRELESS, REMOTE MONITORING DEVICE THAT CONNECTS TO A SMARTPHONE APP WITH ACCURATE MEASUREMENTS”. The final report should not exceed 15 pages including drawings and references. The report should be organized as a written version of the marketing pitch that generally includes the following :

• Cover slide

• Elevator statement

• The clinical need

• The solution

• The market

• Intellectual property (IP)

• R&D

• Regulatory strategy

• Clinical studies

• Reimbursement

• Business model

• Marketing and sales

• Financial information

• Exit scenarios

• The ask

• Management team

• Closing slide

• Appendix

and should include the information outlined in table 6.2.3 as I posted in the above picture of the table called “Development Timeline”.

Using the data safety sheets: 

Sulfuric Acid:

msds (fishersci.ca)

PCI: Phenol-Chloroform: 

15596026_MTR-NALT_EN.pdf (thermofisher.com)

Answer the following questions:

1. What is the physical state, appearance and odour of the product?

PCI SDS:

Sulfuric Acid SDS:

2. What are the specific gravity, freezing and boiling points?

PCI SDS:

Sulfuric Acid SDS:

3. Is the product considered stable? What conditions should be avoided and what incompatibilities should be avoided?

PCI SDS:

Sulfuric Acid SDS:

4. Is the product have any long-term health effects, signs, or symptoms of exposure?

PCI SDS:

Sulfuric Acid SDS:

5. What is the LC50 or LD50? What does this mean?

PCI SDS:

Sulfuric Acid SDS:

6. What information would you use to create a workplace label for this hazard? List the information in your answer as if it were a label.

PCI SDS:

Sulfuric Acid SDS:

Using the data safety sheet: 

PCI: Phenol-Chloroform: 

15596026_MTR-NALT_EN.pdf (thermofisher.com)

Answer the following questions:

1. Find one Hazard and one Precautionary statement for the SDS.

PCI SDS:

Sulfuric Acid SDS:

2. List some acute and chronic effects caused by the product?

PCI SDS:

Sulfuric Acid SDS:

3. What are some first aid measures if the product is in contact with the skin, eyes, or inhaled or ingested?

PCI SDS:

Sulfuric Acid SDS:

4. What are some of the personal protective equipment used when handling the product?

PCI SDS:

Sulfuric Acid SDS:

5. Is the product flammable or combustible? If so what is the Flash Point?

PCI SDS:

Sulfuric Acid SDS:

6. How would you extinguish a fire if the product catches fire?

PCI SDS:

Sulfuric Acid SDS:

7. How would you clean up a spill or leak?

PCI SDS:

Sulfuric Acid SDS:

Using the data safety sheets: 

Sulfuric Acid:

msds (fishersci.ca)

PCI: Phenol-Chloroform: 

15596026_MTR-NALT_EN.pdf (thermofisher.com)

Answer the following questions:

1. Find one Hazard and one Precautionary statement for the SDS.

PCI SDS:

Sulfuric Acid SDS:

2. List some acute and chronic effects caused by the product?

PCI SDS:

Sulfuric Acid SDS:

3. What are some first aid measures if the product is in contact with the skin, eyes, or inhaled or ingested?

PCI SDS:

Sulfuric Acid SDS:

4. What are some of the personal protective equipment used when handling the product?

PCI SDS:

Sulfuric Acid SDS:

5. Is the product flammable or combustible? If so what is the Flash Point?

PCI SDS:

Sulfuric Acid SDS:

6. How would you extinguish a fire if the product catches fire?

PCI SDS:

Sulfuric Acid SDS:

7. How would you clean up a spill or leak?

PCI SDS:

Sulfuric Acid SDS:

Using the data safety sheets: 

msds (fishersci.ca)

15596026_MTR-NALT_EN.pdf (thermofisher.com)

Answer the following questions:

1. What is the product identifier (name)? Are there any other “trade” names for the product?

PCI SDS: 

Sulfuric Acid SDS:

2. What is the company that manufactured/distributed the product?

PCI SDS: 

Sulfuric Acid SDS: 

3. What ingredients make up the composition of the product?

PCI SDS:

Sulfuric Acid SDS:

4. What are the CAS registry numbers for the “products”?

PCI SDS:

Sulfuric Acid SDS:

5. What are the GHS Classifications associated with the product? (WHMIS symbols and categories)

PCI SDS:

Sulfuric Acid:

Using the data safety sheets: 

Sulfuric Acid:

msds (fishersci.ca)

PCI: Phenol-Chloroform: 

15596026_MTR-NALT_EN.pdf (thermofisher.com)

Answer the following questions:

1. What is the product identifier (name)? Are there any other “trade” names for the product?

PCI SDS: 

Sulfuric Acid SDS:

2. What is the company that manufactured/distributed the product?

PCI SDS: 

Sulfuric Acid SDS: 

3. What ingredients make up the composition of the product?

PCI SDS:

Sulfuric Acid SDS:

4. What are the CAS registry numbers for the “products”?

PCI SDS:

Sulfuric Acid SDS:

5. What are the GHS Classifications associated with the product? (WHMIS symbols and categories)

PCI SDS:

Sulfuric Acid:

1. Consider a parallel circuit as shown in lecture. Given V=12 V, R1 = 987 Ω, R2 = 1,047 Ω, and R3 = 2,383 Ω. As a round number, the total resistance in Ohms (Ω) is.

2. Consider a parallel circuit as shown in lecture. Given V=11.3 V, R1 = 1,004 Ω, R2 = 908 Ω, and R3 = 2,100 Ω. The total resistance in Ohms rounded to the nearest whole number is.?