BIO370Y5 Final: study guide for exam
Document Summary
structure: cell walls of the archaea. halococcus & others: outer membrane of gram-negative bacteria. Prescott 8th ed: chapter 3 pages 57-58 and 63-65; chapter 18 pages 473-477. A number of enzymes known to cause the decomposition. Lysozyme - breaks -1,4 glycosidic bonds (product monosaccharides) Muramidase - breaks -1,4 glycosidic bonds (product disaccharides) Penicillin: first discovered by ernest duchesne (1896), but discovery lost, accidentally discovered by alexander fleming (1928) did not think could be developed further: effectiveness demonstrated by florey, chain, and heatley (1939, fleming, florey and chain received nobel prize in 1945 for discovery and production of penicillin www. notesolution. com. Penicillinase - enzyme produced by penicillin resistant bacteria. Narrow & broad spectrum: the -lactam region of the drug resembles the d-ala-d-ala end of the peptide to which the transpeptidase enzyme binds. Much more effective against pbp1a, 1b & 2 than pbp4 ! www. notesolution. com. penicillin can not get to the site of action gram-negative bacteria.
