Microbiology and Immunology 2500A/B Lecture Notes - Contraindication, Kidney Transplantation, B Cell
27 Nov 2012
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Document Summary
Discuss why transplantation is a desirable goal for chronic organ disease and discuss organ shortage. Discuss basic immunology of all responses, including the role of hla and t cell interactions. Discuss the major current strategies of immunosuppression and their risks. Discuss how patients are matched to potential donors, including abo blood grouping, hla matching. Discuss the clinical presentation, lab findings and differential diagnosis of acute graft dysfunction (including rejection) Kidney failure: functioning at less than 15, kidney failure is usually silent, and is caused by many different factors. Transplantation: deceased donor most common. Best option for patients with kidney disease who are suitable to receive a transplant. Not a cure disease is still present. Improved quality of life / life saving: no dialysis, decreased cardiovascular risk, no diet or fluid restrictions, more normal lifestyle (freedom) Transplantation offers patients with end-stage renal disease (esrd) the greatest potential for increased longevity and enhanced quality of life vs. dialysis.
