PSL425H1 Lecture Notes - Lecture 3: Lipoprotein Lipase, Pyruvic Acid, Lipid Signaling
Document Summary
Lipid defined by the insolubility of water (physical property) Cooh (acid) end at the end; long or short aliphatic chains. Triglyceride: esters of fatty acids and a poly-aocohol: glycerol (derived in body from glycolysis) Phospholipid: more complex lipid, some similar to tg, but with a phosphate on instead of 3rd fa. Most of the complex lipids make up mmbrn. Cholesterol metabolism important in atherosclerosis, important for mmbrn structure, Increasing complexity down the column (in relation to the slide); sphingolipids complex phospholipids and cholesterol provide some signaling molecules. Lipids in terms of energy metabolism ketones: acids, some solubility in water, but still grouped with the lipids, they are metabolic products of fa oxidation. Sterols: includes cholesterol and steroid hormones that are derivatives (sex hormones, adrenal steroids, vitamin d that is sterol-like) of cholesterol, detergents (bile salts also made from cholesterol) 3rd carbon including cooh (fa undergo beta oxidation at this site) Most fa in circulation are long fa, 14-22.
