Biochemistry 3380G Lecture Notes - Triglyceride, Coenzyme Q10, Mitochondrial Matrix

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Triacylglycerol breakdown commences in adipocytes (fat storage cells) under low glucose conditions where hormone-insensitive lipase removes glycerol from fatty acids. This action results in fatty acids and glycerol as products. Fatty acids go the liver and muscles (not the brain, it is looking for glucose) and are converted to acetyl coa via -oxidation. Glycerol molecules go to the liver and are fuel for gluconeogenesis. Coenzyme a helps fatty acids cross the inner mitochondrial membrane (fatty acyl-coa is transported into the mitochondrial matrix). This reaction requires the use of both the and phosphates (uses as much energy as possible), but is a good energy investment in the long run. The high energy sulphur bond in acyl-coa is also a notable quality of the molecule. Note that acyl is a prefix for what is left over after the fatty acid joins to coa. In the -oxidation of fatty acids, 2 carbons are being cleaved after each turn of the citric acid cycle.

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