Biology 2382B Lecture Notes - Guanine, Cyclic Adenosine Monophosphate, Transcription Preinitiation Complex
9 Dec 2012
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Document Summary
Phosphorylation found to play a large role in many of these pathways . Response elements - characteristic nucleotide sequences of the dna sites that bind nuclear receptors. Absence of hormone (ligand) receptor is trapped in the cytoplasm by inhibitor proteins that bind to it (e. g. hsp90) Glucocorticoid - a potent anti-inflammatory and immunosuppressive hormone also has many other functions: glucocorticoid receptor found in cytoplasm in inactive state when not bound to steroid hormone ligand. In presence of glucocorticoid activated and moves into the nucleus (nuclear translocation) and dimerizes to form a homodimer: homodimer can then bind to the response element sequence of dna. Net effect = opening up of dna by recruiting a variety of other proteins this makes. Dna more available to transcription and increases gene expression . Basic concepts of signal transduction: hydrophilic ligand cannot cross pm must bind to transmembrane receptor protein, binding of ligand causes a conformational change in the receptor proteins cytosolic domain.
