Biochemistry 2280A Lecture Notes - Reading Frame, Conformational Change, Phenylalanine
12 Dec 2012
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Document Summary
Missense mutation results in a single amino acid change: may or may not have affect on the protein. Frameshift mutation insertion or removal of bases. Insertion or deletion of a base results in a change in reading frame of the protein from the point of mutation onward. Nonsense mutation results in premature termination of the protein: usually have functional consequence, truncates protein from that point onwards trna. Bring the amino acid to the growing polypeptide chain. 2d cloverleaf structure due to internal base pairing (stems and loops: three loops t loop, d loop, anticodon loop, all rnas have complex structures as they are single stranded. 2 key single stranded regions: 3" acceptor site is at the 3" end which is the region that attaches to the amino acid. All trnas end with cca, that is added post-transcriptionally: anticodon base pairs with the codon. In 3d, the trnas look like an l. Most organisms have fewer than 45 different trnas.
