BIOL 300 Lecture Notes - Transcription Factor Ii D, Rela, Sp1 Transcription Factor
15 Dec 2012
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Document Summary
Genes in a eukaryotic dna sequence are normally in a tightly condensed chromatin structure which must first be loosened up for the transcription machinery to get inside the dna grooves. Activating transcription involves getting from the beginning state on top to the open and ready state in the bottom with all proteins assembled. Rna pol; this was studied through in vitro assays. Protein) is a subunit of tfiid which binds to the dna. Other tfiis (b, f which carries rna pol ii, e, h) associate with the complex now attached to the dna: remember, the ctd is responsible for allowing elongation to occur. The pre-initiation complex is the material around the dna (i. e. pol ii and all of the general tfs) Transcription of a gene is regulated by regulatory sequences which can be quite far from the promoter: Dr. lasko located within introns or downstream of the transcription termination site. Pol ii core promoter elements include the following:
