HMB441H1 Lecture Notes - Lecture 7: Haloperidol, Catechol-O-Methyl Transferase, Candidate Gene

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There are no signs in the brain indicating someone has it if you were to cut open and look at brain. Alogia (lack of words), avolition (lack of drive/motivation) Some children develop it before age 12, will go on to have a severe course of the disease. In urban environment the disease results seem to be worse for schizo patients because more expectations compared to rural. Parkinsonism overdose of dopamine associated with developing parkinson"s disease. Useful to tailor treatments because you see what kind of low doses you can get away with i. e. see how much percentage of the receptors the chemical is binding to (85% usually good amount) Candidate gene approach focuses on one gene or snip, unlike whole-genome approach. Many of the rare variants are very penetrant compared to common variants. Neurexin1 involved in dd (developmental delays), schizo, and autism. Can measure thickness of cortex by measuring distance between white/grey matter intersection and the top of brain.

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