BIOL201 Lecture Notes - G2 Phase, Cell Adhesion, Securin
17 Dec 2012
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Biology 201 key terms to know: activated mitotic cdk-cyclin phosphorylates laminin proteins (depolymerization of nuclear envelope), phosphorylates condensin, and phosphorylates mt-associates proteins (spindle formation is initiated). Complex activates anaphase promoting complex: adherens junctions continuous belt around interacting cells, typically in the epithelial cells. They are found in the apex, below the tight junction. Held together by cadherins: anaphase sister chromatids separate, chromatids are pulled to opposite poles via mt shortening. Anaphase promoting complex is the signal: anaphase promoting complex ubiquitin ligase that targets cell proteins for degradation. The destruction of securing allows separase to cleave cohesions that hold sister chromatids together. Degradation of mitotic cyclin depresses mitotic cdk activity, leading to cytokinesis, chromosome decondensation, and nuclear envelope reformation: anchoring junctions connect the cytoskeleton of one cell to another or to the ecm. Able to undergo severe mechanical force: angiogenesis the physical process through which new blood vessels form.
