BCH210H1 Study Guide - Hi-Nrg, Pyruvate Dehydrogenase, Acetyl-Coa
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BCH210H1 Full Course Notes
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Bch210h lisa zhao 2012 | page 1. During muscle contraction, atp is converted to adp. Atp level falls as nrg is used in contraction. Phosphocreatine are phosphate donors that supply atp. Pcr are in higher levels in muscle. Pcr supports atp by giving its p to adp to make atp this rxn is favourable bc pcr has a higher g of hydrolysis than -p in atp. When pcr is diminished, need glucose from blood. Glucose enters muscle cell by glut4 (transporter) Glut4 allows glucose to flow down its conc gradient. Glucose is used to support glycolysis (breaking of sugar in the muscle cytoplasm) Aerobic glycolysis breaks glucose into 2 3-c pyruvate molecules. Pyruvate is joined by atp production from glycolysis and nadh is generated. Pyruvate then goes into mitochondria through pyruvate transporters inner membrane of mitochondria has the transport fxs. Pyruvate dehydrogenase (pdh) complex (a multienzyme complex) takes co2 away from pyruvate, leaving an acetyl group (2-c) and nadh.
