BIO 1140 Lecture Notes - Signal Recognition Particle, Signal Peptidase, Signal Peptide

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When proteins are released from the ribosome, their fate is till uncertain. Protein trafficking / sorting / targeting is important because proteins must go to the right place in order to function. They interact with other macromolecules and within the correct context (within the correct part of the cell) Proteins achieve context by participating in reactions (i. e. : metabolic functions; proteins involved in photosynthesis must go into the to interact with all the other proteins involved with photosynthesis) chloroplast. Signals are part of the amino acid sequence that are recognized by a receptor. The model always involves a signal and a receptor. All proteins (except proteins made in organelles) are translated in the cytoplasm. Examples of protein targeting and mechanisms: endoplasmic reticulum. Rough er is involved in the export of proteins. Rough er is a consequence of the simultaneous synthesis and transportation of proteins: apoplast.

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