BIOL354 Lecture Notes - Lecture 14: Polycyclic Aromatic Hydrocarbon, Cytochrome P450, Pyrene
25 Dec 2012
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Lecture 14 biochemical and physiological effects of chemicals part ii organic pollutants. Organics: complex molecules compare to inorganics, more specific interactions & more mechanisms. Innate form is relatively unreactive/stable, are pro-carcinogens & causes narcosis only @ high []s. Can be metabolized & are photoactive (absorbs uv radiation toxicity), do not magnify: e. g. Cigarette, nicotine do not cause cancer but addiction; the most stable pah - benzo(a)pyrene is formed during combustion & it is carcinogenic. Not direct cause & effect but benzo(a)pyrene is one of the major carcinogens in cigarettes (correlations only, not proof tests are too expensive to conduct) Oxypahs/pah quinones (oxidized aromatic compounds): highly reactive, very toxic @ low []s, cytotoxic, genotoxic & mutagenic (carcinogenic). 3 mechanisms to activate pahs: photochemical activation. Pahs within the organism absorbs uv radiation as exposed to light (photosensitization) Pre exposure of pahs (in or out of the cell) to uv photomodification/photooxidation of.
