CSB327H1 Lecture Notes - Lecture 16: Ovarian Cancer, Abdominal Cavity, Metastasis

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The stroma plays a critical role in cancer progression. Peritoneal metastasis is distinct from hematological (blood-borne) metastasis. Hematological (blood-borne) metastasis is a multi-step and inefficient process. Peritoneal metastasis: shared by ovarian cancer and gastrointestinal tract cancer, localized within the abdominal cavity, primary site of tumour formation (not the cause of death) From gastrointestinal cancers that have invaded through the peritoneal membrane. From surgical perforation: cancer cells exfoliate into peritoneal fluid and spread locally to secondary sites (cause of death, poor prognosis. Diagnosed at late stage after peritoneal metastasis. Peritoneal metastasis proceeds rapidly: peritoneal membrane structure. Single layer of mesothelial cells with underlying ecm (e. g. , fn, ci, civ, lm) Covers the vast surface of abdominal cavities and visceral organs. Secrete ha and proteoglycans: provides anti-adhesive peritoneal surface, promotes gliding. Conceal collagen i matrix (stroma: prevents cancer cell attachment, collagen i is the preferred substratum for ovarian cancer cell attachment and migration.

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