CSB327H1 Lecture Notes - Lecture 12: Syndecan, Paxillin, Focal Adhesion
28 Dec 2012
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Document Summary
The major of cell surface heparin sulfates. Hs-gags bind to fn to activate intracellular signalling events that stabilize fa. Hs-gags bind to several growth factors to present them to their cognate receptors. Hs-gags bind to and present fgf to their cognate fgfr on the same cell. Cs-gags: single-span tm domain, short endodomain (c-terminus) Pi3k generates pi docking sites: pi pip pip2. Regulation of focal adhesion turnover by syndecan-4: syndecan-4 underexpression forms smaller fa and decrease cell motility, syndecan-4 overexpression forms larger fa and decrease cell motility, syndecan-4 maintains an intermediate state of adhesion to promote cell migration. Mechanism: binding of fn to 5 1 integrin increase the level of pip2. Pkc recruits syndesmos to pm syndesmos binds to paxillin promotes fa stability. Integrin-mediated fa formation is dependent on syndecan-4: cell binding domain of fn. No fa formation: cell binding domain of fn + activating ab against syndecan-4.
