Microbiology and Immunology 2500A/B Study Guide - Clostridia, Asymptomatic Carrier, Dpt Vaccine
6 Jan 2013
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Obligate anaerobes (veg. cells killed by o) (>80 species) Dipicolinic acid complex with ca2+ dehydrate cortex gel consistency (pasteurizing won"t kill- 60-70 c ; autoclaving kills 121c: c. difficile- pseudomembranous colitis. Can exist as: a) asymptomatic carrier, b) mild-moderate diarrhea, c) life-threatening pseud colitis. Exists in large intestine in low numbers. Recent antibiotic kill normal flora & stress so form endospore then germinate, grow, make toxins. Does not invade but toxins do damage. A domain: active with enzymatic activity- get this inside host cell. A domain enzyme inactivates host g-proteins rearrange cytoskeltn cell death/inflamma"n. Epithelial layers peel off pseudomembrane and inflammation yellow lesions. Avoid anti-diarhheal- want to get rid of toxins. *new*: restore microbiota from healthy patient- effective- but need to screen donors: c. tetani- tetanus. Tetanus toxoid vaccine (tdap group) 100% protected- problem in developing countries. Colonization of deep wound (anoxic conditions needed) A-b neurotoxin- enters motor neuron, moves retrograde into cns & affects inhibitory neuron.
