BLG 144 Lecture Notes - Fragment Antigen-Binding, Humoral Immunity, B Cell

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11 Jan 2013
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Secreted by b-lymphocytes and produced in response to a specific (foreign) non-self antigen. Each antibody is produced by one type of b-lymphocyte for only one type of antigen. Lymphocytes undergo maturating before birth, producing different types of lymphocytes. Humoral response - b lymphocytes: produce and release antibodies into blood plasma, produce antibodies from b plasma cells, recognize foreign antigen directly. Cellular response - t lymphocytes: bind to antigen carrying cells and destroy them and/or activate the humoral response, recognize foreign antigens displayed on the surface of normal body cells. Primary response produces memory cells which remain in the circulation. Secondary response new invasion by same antigen at a lower state. Immediate recognition and distraction by memory cells -faster and larger response usually prevents harm. Response for pathogens not entering our cells (e. g. bacterium) Each b-lymphocyte recognizes only one specific antigen / need t-helper cell to be activated.

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