BIOL 1602 Lecture Notes - Psychological Stress, Psychosis, Cortisol
Document Summary
Zakzanis; conclusion tha the specific role of deficits in the temporal lobes has been overstated and that more diffuse dysfunction exists. Mri studies found a subtle 4% but significant bilateral hippocampal volume reduction in ppl with s. Regional volume reductions were esp marked in bilateral medial temporal lobe regions. Reported finding reduced hippocampus volume amog twins with s relative to twins without s. They reported that ppl had smaller medial temporal lobe volumes relative to controls but that the volume diff was not specific for either region or hemisphere. Reduced cerebral blood volume accompanies brain size in s and proposed that chronic cerebral blood volume eventually results in neuronal loss and cognitive impairments. The results suggested that violet ppl with s and a history of anti social and or substance use manifest neural dysfunction affecting basal or orbital pats or the prefrontal cortex.
