KIN 191 Lecture Notes - Resting Potential, Hyperphosphatemia, Bone Tumor

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16 Jan 2013
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More adipose tissue > smaller proportion of water in body (women have smaller water proportion) Intracellular fluid compartment > all fluid in trillions of body cells, all cells have similar composition, 40% of body weight. Extracellular fluid compartment: all fluid outside cells, 20% of body weight. Divided into sub compartments > interstitial fluid and plasma. Other compartments: lymph, cerebrospinal fluid, synovial fluid (small volumes) Osmotic pressure of most fluid sub compartments is about equal (water/ion exchange occurs between sub compartments), fluid composition is different, large molecules (proteins) are restricted in movement, cannot penetrate membranes that separate fluid sub compartments. If composition of one sub compartment is altered, fluid exchange may not be equal. Edema: fluid shifts from plasma to isf because of> increase in permeability of capillary walls (inflammation), water moves in same direction because of osmosis. Edema can result from change in hydrostatic pressure across capillary walls.

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