BIOL 2P92 Lecture Notes - Allele, Genetic Drift, Immunodeficiency

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Short-sighted evolution is not the only reason hiv infection is fatal: there is evidence that there are rare strains of hiv exist that kill their hosts more slowly than common strains. Important point is that, alterations to hiv"s genome can render the virus less damaging to the host, but still able to survive in the host"s body. If the host lives longer, then the hiv population persists longer too. Strains that are good at getting transmitted to new hosts will become more common over time; strains that are bad at getting transmitted will disappear. Hiv-2 is less common worldwide than hiv-1. Hiv-2 is a related virus that humans acquired from a different primate species. It is less damaging to its hosts than hiv-1. Individuals infected with hiv-2 do progress to aids, but they do so much more slowly than individuals infected with hiv-1.

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