BIO 2110 Lecture Notes - Lecture 6: Galactose, Adaptive Immune System, Antigen
21 Jan 2013
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In terms of drug development, on average, it takes typically, 500 thousands compound to make an active drug, 2 classic approaches: disjunction approach: dissection, logical of a lead drug. Both use the best existing lead structures, each group will work on one compound: conjunction : Duration of action increasing the half life, moderate the dosage, neo f the classic things u see is. If you have a delayed release, you can have it for the rest of the day, in vitamins, drugs, in salbutamol, how to modify the alkyl group. Systematic synthesis and evaluation of simpler and simpler analogs. This approach hones in and identifies the key structural moiety responsible for the pharmacological activity. 3)molecular hyberdization : association of different or mixed moieties through covalent bonds taking all different types of moedies and put them together, 3-chiral centers : usings chiral centers is cleaver in pharma introducing.
