EHJ352H1 Lecture Notes - Lecture 5: Mutation Rate, Single-Nucleotide Polymorphism, Genome Size

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What would a simple genome look like: just the protein coding genes ( and a minimal amount of additional regulatory dna, protein coding genes not separated into pieces (exons) by other sequence (intron) Gene number varies much less than gene density: gene number is the amount of functional genes, and that does not vary as much. Humans have 24000 and yeast has around 6000. However humans gene density is a lot less than yeast since humans has a larger genome size. Gains of sequence are more common than loss of sequences (transposable elements) Lynch argues that there is an insertional bias although data are somewhat mixed. Dangers of a larger genome: metabolic costs of dna: energy is needed to replicate dna. Non-functional neutral dna can be target for deleterious gain of function. Transcription factor (tf) binding motifs are under-represented in non-coding regions, presumably as a result of selection. Insertion of tes in non-coding regions often alters expression of neighboring genes.

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