EHJ352H1 Lecture Notes - Lecture 17: Reproductive Isolation, Denisovan, Neanderthal Genome Project
26 Jan 2013
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Document Summary
Conclusions about human history from human population genetics: Recent shared ancestry from relatively small founding population in africa. Increased genetic bottlenecks with distance from africa, consistent with model of serial founder events. Real world likely more complicated, e. g. long-distance migration. Models of human evolution: single origin model: the other lineages are here but they did not have anything to do with humans. Still a lot of shared polymorphisms: high-migration model: some gene flow between different species, modern humans extend from one of these lineages, low-migration model: still humans extend from a single lineage. Isolation and admixture model: after the origin of modern humans, some subset of humans experience gene flow from another lineage. Africa exchanged genes with neanderthal and other lineages. Coalescent times are highly variable across genes: A lot of coalescent time frames goes much further back to 2000 years ago - the origin of modern humans.
